Whole-genome analysis of EC129, an NDM-5-, CTX-M-14-, OXA-10- and MCR-1-co-producing Escherichia coli ST167 strain isolated from Japan.

Anti-Bacterial Agents / pharmacology Carbapenem-Resistant Enterobacteriaceae Drug Resistance, Multiple, Bacterial / drug effects Escherichia coli / drug effects Escherichia coli Proteins / genetics Genes, Bacterial / genetics Genome, Bacterial Japan Microbial Sensitivity Tests Whole Genome Sequencing beta-Lactamases / genetics
Escherichia coli NDM-5 Whole-genome sequencing mcr-1

Journal

Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459

Informations de publication

Date de publication:
09 2019
Historique:
received: 06 06 2019
revised: 19 06 2019
accepted: 01 07 2019
pubmed: 12 7 2019
medline: 23 6 2020
entrez: 12 7 2019
Statut: ppublish

Résumé

The emergence and spread of carbapenemase-producing Enterobacteriaceae is a worldwide concern. This study reports the whole genome sequence of an NDM-5-, CTX-M-14-, OXA-10- and MCR-1-co-producing Escherichia coli sequence type 167 (ST167) multidrug-resistant clinical strain (EC129) isolated from a sputum sample of a hospitalised patient diagnosed with pneumonia. The genome of E. coli EC129 was subjected to next-generation sequencing and reads were assembled. The draft genome was annotated using DDBJ Read Annotation Pipeline DFAST server, followed by subsequent in silico analysis. The genome of E. coli ST167 strain EC129 is 5319159 bp in length and contains 5022 protein-coding sequences. The bla To our knowledge, this study is the first to report anE. coli ST167 strain co-producing NDM-5, CTX-M-14, OXA-10 and MCR-1 isolated from a sputum sample of an individual with pneumonia in Japan, thus elucidating the molecular characteristics and resistance gene diversity of this strain.

Identifiants

DOI: 10.1016/j.jgar.2019.07.001 PMID: 31295582
pubmed: 31295582
pii: S2213-7165(19)30167-5
doi: 10.1016/j.jgar.2019.07.001
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Escherichia coli Proteins 0
MCR-1 protein, E coli 0
beta-lactamase CTX-M-14, E coli EC 3.5.2.-
beta-lactamase OXA-10 EC 3.5.2.-
beta lactamase NDM-5, E coli EC 3.5.2.6
beta-Lactamases EC 3.5.2.6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

148-150

Informations de copyright

Copyright © 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd. All rights reserved.

Auteurs

Yoko Nukui (Y)

Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: nucku-tky@umin.ac.jp.

Alafate Ayibieke (A)

Department of Molecular Microbiology, Tokyo Medical and Dental University, Tokyo, Japan.

Makoto Taniguchi (M)

Oral Microbiome Center, Kagawa, Japan.

Yoshibumi Aiso (Y)

Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan.

Yuka Shibuya (Y)

Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan.

Kazunari Sonobe (K)

Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan; Department of Clinical Laboratory, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan.

Jun Nakajima (J)

Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan; Department of Clinical Laboratory, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan.

Saki Kanehira (S)

Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan; Department of Clinical Laboratory, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan.

Yoshiro Hadano (Y)

Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan.

Shuji Tohda (S)

Department of Clinical Laboratory, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan.

Ryuji Koike (R)

Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan.

Ryoichi Saito (R)

Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo, Japan; Department of Molecular Microbiology, Tokyo Medical and Dental University, Tokyo, Japan.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Whole-genome analysis of EC129, an NDM-5-,...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Enterobacteriaceae résistantes aux carbapénèmes › Whole-genome analysis of EC129, an NDM-5-,...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Multirésistance aux médicaments › Multirésistance bactérienne aux médicaments › Whole-genome analysis of EC129, an NDM-5-,...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Whole-genome analysis of EC129, an NDM-5-,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines Escherichia coli › Whole-genome analysis of EC129, an NDM-5-,...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Gènes bactériens › Whole-genome analysis of EC129, an NDM-5-,...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Whole-genome analysis of EC129, an NDM-5-,...
questionsmedicales.fr › Régions géographiques › Iles › Japon › Whole-genome analysis of EC129, an NDM-5-,...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Whole-genome analysis of EC129, an NDM-5-,...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Whole-genome analysis of EC129, an NDM-5-,...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › Whole-genome analysis of EC129, an NDM-5-,...