Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases.
Animals
Autoimmune Diseases
/ complications
Autoimmunity
Cell Differentiation
Cytokines
/ metabolism
Disease Management
Disease Susceptibility
/ immunology
Humans
Immunomodulation
Inflammation
/ immunology
Inflammation Mediators
/ metabolism
Interleukin-17
/ metabolism
Interleukin-23
/ metabolism
Periodontitis
/ diagnosis
Signal Transduction
Th17 Cells
/ cytology
Crohn’s disease
Sjögren syndrome
Th17 cells
cytokines
interleukin-17
interleukin-23
periodontitis
psoriasis
rheumatoid arthritis
systemic lupus erythematosus
type 1 diabetes mellitus
ulcerative colitis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Jul 2019
10 Jul 2019
Historique:
received:
23
05
2019
revised:
11
06
2019
accepted:
08
07
2019
entrez:
13
7
2019
pubmed:
13
7
2019
medline:
21
12
2019
Statut:
epublish
Résumé
Innate immunity represents the semi-specific first line of defense and provides the initial host response to tissue injury, trauma, and pathogens. Innate immunity activates the adaptive immunity, and both act highly regulated together to establish and maintain tissue homeostasis. Any dysregulation of this interaction can result in chronic inflammation and autoimmunity and is thought to be a major underlying cause in the initiation and progression of highly prevalent immune-mediated inflammatory diseases (IMIDs) such as psoriasis, rheumatoid arthritis, inflammatory bowel diseases among others, and periodontitis. Th1 and Th2 cells of the adaptive immune system are the major players in the pathogenesis of IMIDs. In addition, Th17 cells, their key cytokine IL-17, and IL-23 seem to play pivotal roles. This review aims to provide an overview of the current knowledge about the differentiation of Th17 cells and the role of the IL-17/IL-23 axis in the pathogenesis of IMIDs. Moreover, it aims to review the association of these IMIDs with periodontitis and briefly discusses the therapeutic potential of agents that modulate the IL-17/IL-23 axis.
Identifiants
pubmed: 31295952
pii: ijms20143394
doi: 10.3390/ijms20143394
pmc: PMC6679067
pii:
doi:
Substances chimiques
Cytokines
0
Inflammation Mediators
0
Interleukin-17
0
Interleukin-23
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Inflamm Bowel Dis. 1999 Nov;5(4):285-94
pubmed: 10579123
Lancet. 2000 Feb 26;355(9205):735-40
pubmed: 10703815
J Exp Med. 2000 Jul 3;192(1):123-8
pubmed: 10880533
Ann Allergy Asthma Immunol. 2000 Jul;85(1):9-18; quiz 18, 21
pubmed: 10923599
Immunity. 2000 Nov;13(5):715-25
pubmed: 11114383
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7461-8
pubmed: 11390983
J Exp Med. 2001 Aug 20;194(4):519-27
pubmed: 11514607
Inflamm Res. 2002 Feb;51(2):102-4
pubmed: 11930902
Gut. 2003 Jan;52(1):65-70
pubmed: 12477762
J Immunol. 2003 Feb 15;170(4):2153-60
pubmed: 12574388
Nature. 2003 Feb 13;421(6924):744-8
pubmed: 12610626
J Biol Chem. 2004 Jan 23;279(4):2559-67
pubmed: 14600152
J Immunol. 2003 Dec 1;171(11):6173-7
pubmed: 14634133
J Exp Med. 2003 Dec 15;198(12):1951-7
pubmed: 14662908
Clin Immunol. 2004 Jan;110(1):55-62
pubmed: 14962796
J Exp Med. 2005 Jan 17;201(2):233-40
pubmed: 15657292
Ann Rheum Dis. 2005 Mar;64 Suppl 2:ii30-6
pubmed: 15708932
J Clin Periodontol. 2005 Apr;32(4):383-9
pubmed: 15811056
Lancet. 2005 Jul 23-29;366(9482):321-31
pubmed: 16039337
Nat Immunol. 2005 Nov;6(11):1123-32
pubmed: 16200070
Oral Microbiol Immunol. 2005 Dec;20(6):382-6
pubmed: 16238600
Immunity. 2006 Feb;24(2):179-89
pubmed: 16473830
J Clin Invest. 2006 May;116(5):1218-22
pubmed: 16670765
Ann Rheum Dis. 2007 Jun;66(6):712-9
pubmed: 16901957
Cell. 2006 Sep 22;126(6):1121-33
pubmed: 16990136
J Exp Med. 2006 Nov 27;203(12):2673-82
pubmed: 17088434
Br J Pharmacol. 2007 Feb;150(3):286-97
pubmed: 17200677
Blood. 2007 May 1;109(9):3794-802
pubmed: 17202320
J Exp Med. 2007 Jan 22;204(1):41-7
pubmed: 17227914
J Dent Res. 2007 Apr;86(4):347-51
pubmed: 17384030
Postgrad Med J. 2007 Apr;83(978):251-60
pubmed: 17403952
Nature. 2007 Jul 26;448(7152):484-487
pubmed: 17581588
Nat Immunol. 2007 Sep;8(9):958-66
pubmed: 17676043
Trends Immunol. 2007 Oct;28(10):429-36
pubmed: 17845865
Nat Immunol. 2007 Dec;8(12):1390-7
pubmed: 17994024
J Exp Med. 2007 Nov 26;204(12):2803-12
pubmed: 18025126
J Rheumatol. 2008 Jan;35(1):70-6
pubmed: 18050377
Handb Exp Pharmacol. 2008;(181):3-18
pubmed: 18071939
Inflamm Bowel Dis. 2008 Apr;14(4):437-45
pubmed: 18088064
Immunity. 2008 Jan;28(1):29-39
pubmed: 18164222
J Clin Periodontol. 2008 Jun;35(6):555-60
pubmed: 18400026
J Biol Chem. 2008 Jun 20;283(25):17003-8
pubmed: 18434325
Lancet. 2008 May 17;371(9625):1665-74
pubmed: 18486739
Lancet. 2008 May 17;371(9625):1675-84
pubmed: 18486740
Gut. 2008 Dec;57(12):1682-9
pubmed: 18653729
J Dent Res. 2008 Sep;87(9):817-28
pubmed: 18719207
Biochem Biophys Res Commun. 2008 Dec 5;377(1):12-6
pubmed: 18796297
Int Immunopharmacol. 2009 Jan;9(1):38-42
pubmed: 18848647
Oral Microbiol Immunol. 2009 Feb;24(1):1-6
pubmed: 19121062
Eur J Immunol. 2009 Mar;39(3):667-9
pubmed: 19283719
Diabetes. 2009 Jun;58(6):1302-11
pubmed: 19289457
J Invest Dermatol. 2009 Jun;129(6):1339-50
pubmed: 19322214
J Clin Periodontol. 2009 May;36(5):396-403
pubmed: 19419438
Am J Pathol. 2009 Sep;175(3):1167-77
pubmed: 19700754
Prescrire Int. 2009 Oct;18(103):202-4
pubmed: 19882785
N Engl J Med. 2010 Jan 14;362(2):118-28
pubmed: 20071701
Clin Exp Immunol. 2010 Jun;160(3):386-93
pubmed: 20089077
Annu Rev Immunol. 2010;28:445-89
pubmed: 20192806
J Dent Res. 2010 Sep;89(9):943-7
pubmed: 20400718
Periodontol 2000. 2010 Jun;53:28-44
pubmed: 20403103
Nature. 2010 Apr 29;464(7293):1293-300
pubmed: 20432533
J Immunol. 2010 Aug 1;185(3):1959-67
pubmed: 20592279
Immunity. 2010 Jun 25;32(6):852-62
pubmed: 20620947
Sci Transl Med. 2010 Oct 6;2(52):52ra72
pubmed: 20926833
F1000 Med Rep. 2009 May 08;1:null
pubmed: 20948750
Am Fam Physician. 2010 Dec 1;82(11):1381-8
pubmed: 21121523
Periodontol 2000. 2011 Feb;55(1):87-103
pubmed: 21134230
Nat Immunol. 2011 Mar;12(3):255-63
pubmed: 21278737
Immunology. 2011 Sep;134(1):8-16
pubmed: 21726218
Sci Transl Med. 2011 Oct 12;3(104):104ra100
pubmed: 21998407
J Immunol. 2011 Nov 1;187(9):4389-91
pubmed: 22013204
Diabetologia. 2012 Jan;55(1):21-31
pubmed: 22057194
J Periodontal Res. 2012 Aug;47(4):525-31
pubmed: 22309127
J Invest Dermatol. 2012 Mar;132(3 Pt 1):506-8
pubmed: 22327261
Arthritis Res Ther. 2012 Mar 14;14(2):R64
pubmed: 22417709
N Engl J Med. 2012 Mar 29;366(13):1190-9
pubmed: 22455413
Ann Rheum Dis. 2012 Oct;71(10):1741-8
pubmed: 22550316
J Am Acad Dermatol. 2012 Nov;67(5):924-30
pubmed: 22664308
J Eur Acad Dermatol Venereol. 2013 Aug;27(8):967-72
pubmed: 22703187
Ann Rheum Dis. 2013 Jun;72(6):863-9
pubmed: 22730366
Br J Dermatol. 2012 Dec;167(6):1338-44
pubmed: 22755552
Lancet. 2012 Nov 3;380(9853):1590-605
pubmed: 22914295
Lancet. 2012 Nov 3;380(9853):1606-19
pubmed: 22914296
Nat Immunol. 2012 Oct;13(10):991-9
pubmed: 22961052
Cell. 2012 Oct 12;151(2):289-303
pubmed: 23021777
Discov Med. 2012 Oct;14(77):253-62
pubmed: 23114581
J Periodontol. 2013 Nov;84(11):1627-37
pubmed: 23327689
Ann Rheum Dis. 2013 Oct;72(10):1700-7
pubmed: 23328939
Nat Rev Rheumatol. 2013 Mar;9(3):141-53
pubmed: 23381558
Genes Cells. 2013 Apr;18(4):247-65
pubmed: 23383714
Eur J Neurol. 2013 Jul;20(7):1053-9
pubmed: 23398363
J Dent (Tehran). 2013 Jan;10(1):23-31
pubmed: 23724200
Ann Rheum Dis. 2013 Dec;72(12):2048-50
pubmed: 23864239
Int J Biol Sci. 2013 Jul 18;9(7):666-79
pubmed: 23904791
Am Fam Physician. 2013 May 15;87(10):699-705
pubmed: 23939448
Clin Dev Immunol. 2013;2013:203705
pubmed: 24187560
J Clin Rheumatol. 2013 Dec;19(8):432-8
pubmed: 24263145
Periodontol 2000. 2014 Feb;64(1):57-80
pubmed: 24320956
Mediators Inflamm. 2013;2013:425915
pubmed: 24382939
Clin Rheumatol. 2014 Apr;33(4):505-9
pubmed: 24415114
World J Gastroenterol. 2014 Jan 7;20(1):91-9
pubmed: 24415861
Autoimmun Rev. 2014 Apr-May;13(4-5):490-5
pubmed: 24434359
Expert Rev Clin Immunol. 2014 Apr;10(4):521-31
pubmed: 24450381
Clin Dev Immunol. 2013;2013:986789
pubmed: 24454481
J Oral Microbiol. 2014 Feb 25;6:null
pubmed: 24578801
Biomed Rep. 2013 Mar;1(2):177-184
pubmed: 24648915
PLoS One. 2014 Mar 20;9(3):e92333
pubmed: 24651659
Sci Transl Med. 2014 Mar 26;6(229):229ra40
pubmed: 24670684
J Clin Periodontol. 2014 Jun;41(6):541-9
pubmed: 24735470
Rheumatology (Oxford). 2014 Oct;53(10):1872-85
pubmed: 24821849
Clin Immunol. 2014 Sep;154(1):1-12
pubmed: 24858580
Expert Rev Clin Immunol. 2014 Aug;10(8):973-5
pubmed: 24931458
Oral Dis. 2015 Apr;21(3):314-9
pubmed: 24989645
Eur J Neurol. 2015 Mar;22(3):588-90
pubmed: 25041906
Curr Opin Rheumatol. 2014 Sep;26(5):520-7
pubmed: 25050925
Trends Pharmacol Sci. 2014 Oct;35(10):493-500
pubmed: 25131183
Arthritis Res Ther. 2014 Aug 22;16(4):426
pubmed: 25146432
Adv Exp Med Biol. 2014;841:15-44
pubmed: 25261203
Immunology. 2014 Sep 29;:null
pubmed: 25263088
Exp Dermatol. 2015 Apr;24(4):241-4
pubmed: 25348334
Inflamm Res. 2014 Dec;63(12):1001-12
pubmed: 25369802
Actas Dermosifiliogr. 2014 Oct;105 Suppl 1:21-33
pubmed: 25398489
Actas Dermosifiliogr. 2014 Oct;105 Suppl 1:34-40
pubmed: 25398490
J Indian Soc Periodontol. 2014 Sep;18(5):666-9
pubmed: 25425834
Cytokine Growth Factor Rev. 2015 Feb;26(1):25-33
pubmed: 25434285
Curr Opin Rheumatol. 2015 Mar;27(2):127-33
pubmed: 25599143
Clin Rheumatol. 2015 Jun;34(6):1019-23
pubmed: 25939522
Lancet. 2015 Sep 5;386(9997):983-94
pubmed: 26025581
Clin Exp Immunol. 2016 Jan;183(1):30-6
pubmed: 26080615
Mediators Inflamm. 2015;2015:205156
pubmed: 26101460
Front Genet. 2015 Jul 14;6:236
pubmed: 26236331
Periodontol 2000. 2015 Oct;69(1):142-59
pubmed: 26252407
Mediators Inflamm. 2015;2015:379626
pubmed: 26347009
Microb Pathog. 2016 May;94:21-6
pubmed: 26375893
Cochrane Database Syst Rev. 2015 Nov 06;(11):CD004714
pubmed: 26545069
Am J Hum Genet. 2015 Dec 3;97(6):816-36
pubmed: 26626624
J Clin Periodontol. 2016 Jan;43(1):26-33
pubmed: 26646777
J Rheumatol. 2016 Feb;43(2):289-97
pubmed: 26669919
Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):14-22
pubmed: 26750756
Int Immunol. 2016 Apr;28(4):163-71
pubmed: 26874355
Immunology. 2016 Jun;148(2):125-39
pubmed: 26878338
J Crohns Colitis. 2016 Aug;10(8):989-97
pubmed: 26896086
Scientifica (Cairo). 2016;2016:7506041
pubmed: 27034903
Rheumatol Int. 2016 Aug;36(8):1065-75
pubmed: 27105880
Clin Immunol. 2017 Dec;185:95-99
pubmed: 27109641
J Clin Cell Immunol. 2016 Apr;7(2):null
pubmed: 27308096
J Eur Acad Dermatol Venereol. 2017 Feb;31(2):288-293
pubmed: 27439545
Clin Exp Dermatol. 2016 Oct;41(7):806-10
pubmed: 27480070
Nat Immunol. 2016 Oct;17(10):1197-1205
pubmed: 27573866
Br J Dermatol. 2017 Jul;177(1):47-62
pubmed: 27580411
World J Gastroenterol. 2016 Sep 21;22(35):7963-72
pubmed: 27672291
J Am Acad Dermatol. 2017 Feb;76(2):334-341
pubmed: 27720274
Oral Dis. 2017 Oct;23(7):854-865
pubmed: 27763707
Essays Biochem. 2016 Oct 31;60(3):275-301
pubmed: 27784777
Clin Exp Immunol. 2017 Apr;188(1):63-78
pubmed: 27880975
Pathog Dis. 2016 Dec;74(9):
pubmed: 27915228
Medicine (Baltimore). 2016 Dec;95(49):e5516
pubmed: 27930541
Br Dent J. 2016 Dec 16;221(12):794-799
pubmed: 27982000
Genes Immun. 2017 Jan;18(1):15-21
pubmed: 28053319
Immunity. 2017 Jan 17;46(1):133-147
pubmed: 28087239
Molecules. 2017 Jan 14;22(1):
pubmed: 28098832
Braz Oral Res. 2017 Jan 16;31:e8
pubmed: 28099577
Int Rev Immunol. 2017 Jan 2;36(1):20-30
pubmed: 28102734
J Clin Periodontol. 2017 Apr;44(4):382-393
pubmed: 28117909
Curr Rheumatol Rev. 2018;14(3):239-245
pubmed: 28124612
J Am Acad Dermatol. 2017 Mar;76(3):377-390
pubmed: 28212759
Arthritis Rheumatol. 2017 Jun;69(6):1144-1153
pubmed: 28217871
Immunity. 2017 Feb 21;46(2):183-196
pubmed: 28228278
Mediators Inflamm. 2017;2017:2405291
pubmed: 28239238
N Engl J Med. 2017 Mar 23;376(12):1141-1146
pubmed: 28328326
PLoS One. 2017 Mar 30;12(3):e0174442
pubmed: 28358812
J Periodontal Res. 2017 Oct;52(5):893-902
pubmed: 28393368
Semin Immunopathol. 2017 Jun;39(4):343-354
pubmed: 28508153
Nat Immunol. 2017 May 18;18(6):612-621
pubmed: 28518156
Am J Clin Dermatol. 2017 Dec;18(6):771-787
pubmed: 28597181
Mayo Clin Proc. 2017 Jul;92(7):1088-1103
pubmed: 28601423
Trends Mol Med. 2017 Jul;23(7):615-635
pubmed: 28623084
J Clin Med. 2017 Jul 05;6(7):
pubmed: 28678161
J Clin Exp Dent. 2017 Jul 1;9(7):e934-e938
pubmed: 28828164
Clin Anat. 2018 Mar;31(2):216-223
pubmed: 28833647
Clin Rheumatol. 2017 Dec;36(12):2733-2741
pubmed: 28988297
J Dermatolog Treat. 2017 Nov 10;:1-6
pubmed: 29058501
PLoS One. 2017 Oct 23;12(10):e0187075
pubmed: 29059229
Mult Scler Relat Disord. 2017 Nov;18:20-25
pubmed: 29141810
Nat Rev Rheumatol. 2017 Nov 21;13(12):707-718
pubmed: 29158574
PeerJ. 2017 Nov 16;5:e4064
pubmed: 29158990
Microbiol Immunol. 2018 Jan;62(1):1-13
pubmed: 29205464
Immunology. 2018 May;154(1):21-27
pubmed: 29315555
Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Mar;125(3):223-231
pubmed: 29325853
J Autoimmun. 2018 Jan 21;:null
pubmed: 29395738
J Eur Acad Dermatol Venereol. 2018 Jul;32(7):1111-1119
pubmed: 29438576
BioDrugs. 2018 Apr;32(2):119-128
pubmed: 29470778
J Dermatolog Treat. 2018 Sep;29(6):569-578
pubmed: 29532693
Bone Res. 2018 Apr 27;6:15
pubmed: 29736302
J Drugs Dermatol. 2018 May 1;17(5):539-542
pubmed: 29742185
J Indian Soc Periodontol. 2018 Mar-Apr;22(2):116-121
pubmed: 29769765
Fogorv Sz. 2016 Dec;109(4):119-124
pubmed: 29949256
Int J Colorectal Dis. 2018 Oct;33(10):1437-1444
pubmed: 30003361
Clin Exp Rheumatol. 2019 Mar-Apr;37(2):208-214
pubmed: 30148445
Ann Pharmacother. 2019 Mar;53(3):276-284
pubmed: 30187769
Ann Pharmacother. 2019 Apr;53(4):413-418
pubmed: 30345790
J Dent Res. 2019 Feb;98(2):148-156
pubmed: 30359170
J Periodontol. 2019 Apr;90(4):358-366
pubmed: 30387155
Lupus. 2018 Oct;27(1_suppl):32-35
pubmed: 30452329
Front Immunol. 2018 Nov 28;9:2746
pubmed: 30555460
Front Immunol. 2018 Dec 10;9:2901
pubmed: 30619268
J Invest Dermatol. 2019 Jul;139(7):1564-1573.e8
pubmed: 30684548
Drug Saf. 2019 Jun;42(6):751-768
pubmed: 30739254
J Dermatolog Treat. 2019 Feb 25;:1-6
pubmed: 30799638
Expert Opin Biol Ther. 2019 Apr;19(4):287-292
pubmed: 30831036
Clin J Gastroenterol. 2019 Mar 5;:null
pubmed: 30838512
J Immunol. 1996 Jan 1;156(1):5-7
pubmed: 8598493
Front Biosci. 1997 Jan 01;2:d12-26
pubmed: 9159205
J Immunol. 1998 Jul 1;161(1):409-14
pubmed: 9647250