Cholinergic and peptidergic neurotransmission in the adrenal medulla: A dynamic control of stimulus-secretion coupling.
Acetylcholine
/ metabolism
Adrenal Medulla
/ growth & development
Animals
Chromaffin Cells
/ metabolism
Humans
Neuropeptides
/ metabolism
Neurotransmitter Agents
/ metabolism
Pituitary Adenylate Cyclase-Activating Polypeptide
/ metabolism
Splanchnic Nerves
/ metabolism
Synapses
/ metabolism
Synaptic Transmission
/ physiology
adrenal stimulus-secretion coupling
cholinergic synapses
peptidergic neurotransmission
postnatal development
splanchnic nerve-chromaffin cell synapses
stress
Journal
IUBMB life
ISSN: 1521-6551
Titre abrégé: IUBMB Life
Pays: England
ID NLM: 100888706
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
15
04
2019
accepted:
18
06
2019
pubmed:
14
7
2019
medline:
22
6
2021
entrez:
14
7
2019
Statut:
ppublish
Résumé
Synaptic neurotransmission at the splanchnic nerve-chromaffin cell synapse is a chief element of the stimulus-secretion coupling in the adrenal medullary tissue, managing and regulating the secretion of catecholamines. Making the state of play more intricate than initially envisioned, the synaptic vesicles of nerve terminals innervating the medulla contain various compounds, including various neurotransmitters and neuropeptides. Under basal conditions associated with a low splanchnic nerve discharge rate, neurotransmission is ensured by the synaptic release of the primary neurotransmitter acetylcholine (ACh). Under sustained and repetitive stimulations of the splanchnic nerve, as triggered in response to stressors, the synaptic release of neuropeptides, such as the pituitary adenylate cyclase-activating polypeptide PACAP, supplants ACh release. The anatomical and functional changes that occur presynaptically at the preganglionic splanchnic nerve, combined with changes occurring postsynaptically at nicotinic acetylcholine receptors (nAChRs), confer the adrenomedullary synapses a solid and persistent aptitude to functional remodeling, from birth to aging. The present review focuses on the composite cholinergic and noncholinergic nature of neurotransmission occurring at the splanchnic nerve-chromaffin cell synapse and its remodeling in response to physiological or pathological stimuli.
Substances chimiques
Neuropeptides
0
Neurotransmitter Agents
0
Pituitary Adenylate Cyclase-Activating Polypeptide
0
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
553-567Informations de copyright
© 2019 International Union of Biochemistry and Molecular Biology.
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