Subfertility and reduced progestin synthesis in Pgrmc2 knockout zebrafish.
Animals
Base Sequence
Female
Gene Expression Regulation
Infertility
/ genetics
Membrane Proteins
/ genetics
Mutation
/ genetics
Oocytes
/ metabolism
Oogenesis
Ovarian Follicle
/ metabolism
Progestins
/ biosynthesis
RNA, Messenger
/ genetics
Receptors, Progesterone
/ genetics
Reproduction
/ genetics
Sexual Maturation
Zebrafish
/ metabolism
Zebrafish Proteins
/ genetics
DHP
Oocyte maturation
Pgrmc2
Progestin
Steroid synthesis
Subfertility
Journal
General and comparative endocrinology
ISSN: 1095-6840
Titre abrégé: Gen Comp Endocrinol
Pays: United States
ID NLM: 0370735
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
received:
10
03
2019
revised:
14
06
2019
accepted:
06
07
2019
pubmed:
14
7
2019
medline:
22
1
2020
entrez:
14
7
2019
Statut:
ppublish
Résumé
Progestin receptor membrane component (Pgrmc1 & 2) is a heme-binding protein. Studies on Pgrmc1 have suggested possible roles in heme binding, activation of steroid-synthesizing P450s, along with binding and transferring of membrane proteins. However, the studies of Pgrmc1's paralog, Pgrmc2 are still lacking. In order to determine the physiologic function(s) of Pgrmc2, we generated a zebrafish mutant line (pgrmc2
Identifiants
pubmed: 31301284
pii: S0016-6480(19)30126-1
doi: 10.1016/j.ygcen.2019.113218
pmc: PMC6718323
mid: NIHMS1535655
pii:
doi:
Substances chimiques
Membrane Proteins
0
Progestins
0
RNA, Messenger
0
Receptors, Progesterone
0
Zebrafish Proteins
0
pgrmc2 protein, zebrafish
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
113218Subventions
Organisme : NIGMS NIH HHS
ID : R15 GM100461
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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