Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches.
ADHD
Anorexia nervosa
Bulimia nervosa
Eating disorders
Genetic epidemiology
Polygenic risk score
Journal
Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
30
01
2019
revised:
15
04
2019
accepted:
22
04
2019
pubmed:
16
7
2019
medline:
18
9
2020
entrez:
15
7
2019
Statut:
ppublish
Résumé
Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472). Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes. We observed stronger genetic association with ADHD for non-AN EDs than for AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders.
Sections du résumé
BACKGROUND
Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa.
METHODS
We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472).
RESULTS
Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes.
CONCLUSIONS
We observed stronger genetic association with ADHD for non-AN EDs than for AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders.
Identifiants
pubmed: 31301758
pii: S0006-3223(19)31371-X
doi: 10.1016/j.biopsych.2019.04.036
pmc: PMC6776821
mid: NIHMS1050240
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
577-586Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : K01 MH109782
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109536
Pays : United States
Organisme : Wellcome Trust
ID : 106047
Pays : United Kingdom
Investigateurs
Roger Adan
(R)
Tetsuya Ando
(T)
Jessica Baker
(J)
Andrew Bergen
(A)
Wade Berrettini
(W)
Andreas Birgegård
(A)
Claudette Boni
(C)
Vesna Boraska Perica
(V)
Harry Brandt
(H)
Roland Burghardt
(R)
Matteo Cassina
(M)
Carolyn Cesta
(C)
Maurizio Clementi
(M)
Joni Coleman
(J)
Roger Cone
(R)
Philippe Courtet
(P)
Steven Crawford
(S)
Scott Crow
(S)
James Crowley
(J)
Unna Danner
(U)
Oliver Davis
(O)
Martina de Zwaan
(M)
George Dedoussis
(G)
Daniela Degortes
(D)
Janiece DeSocio
(J)
Danielle Dick
(D)
Dimitris Dikeos
(D)
Monika Dmitrzak-Weglarz
(M)
Elisa Docampo
(E)
Karin Egberts
(K)
Stefan Ehrlich
(S)
Geòrgia Escaramís
(G)
Tõnu Esko
(T)
Xavier Estivill
(X)
Angela Favaro
(A)
Fernando Fernández-Aranda
(F)
Manfred Fichter
(M)
Chris Finan
(C)
Krista Fischer
(K)
Manuel Föcker
(M)
Lenka Foretova
(L)
Monica Forzan
(M)
Christopher Franklin
(C)
Héléna Gaspar
(H)
Fragiskos Gonidakis
(F)
Philip Gorwood
(P)
Monica Gratacos
(M)
Sébastien Guillaume
(S)
Yiran Guo
(Y)
Hakon Hakonarson
(H)
Katherine Halmi
(K)
Konstantinos Hatzikotoulas
(K)
Joanna Hauser
(J)
Johannes Hebebrand
(J)
Sietske Helder
(S)
Judith Hendriks
(J)
Beate Herpertz-Dahlmann
(B)
Wolfgang Herzog
(W)
Christopher Hilliard
(C)
Anke Hinney
(A)
Laura Huckins
(L)
James Hudson
(J)
Julia Huemer
(J)
Hartmut Imgart
(H)
Hidetoshi Inoko
(H)
Susana Jiménez-Murcia
(S)
Craig Johnson
(C)
Jenny Jordan
(J)
Anders Juréus
(A)
Gursharan Kalsi
(G)
Debora Kaminska
(D)
Allan Kaplan
(A)
Jaakko Kaprio
(J)
Leila Karhunen
(L)
Andreas Karwautz
(A)
Martien Kas
(M)
Walter Kaye
(W)
James Kennedy
(J)
Martin Kennedy
(M)
Anna Keski-Rahkonen
(A)
Kirsty Kiezebrink
(K)
Youl-Ri Kim
(YR)
Kelly Klump
(K)
Gun Peggy Knudsen
(GP)
Bobby Koeleman
(B)
Doris Koubek
(D)
Maria La Via
(M)
Mikael Landén
(M)
Robert Levitan
(R)
Dong Li
(D)
Paul Lichtenstein
(P)
Lisa Lilenfeld
(L)
Jolanta Lissowska
(J)
Pierre Magistretti
(P)
Mario Maj
(M)
Katrin Mannik
(K)
Nicholas Martin
(N)
Sara McDevitt
(S)
Peter McGuffin
(P)
Elisabeth Merl
(E)
Andres Metspalu
(A)
Ingrid Meulenbelt
(I)
Nadia Micali
(N)
James Mitchell
(J)
Karen Mitchell
(K)
Palmiero Monteleone
(P)
Alessio Maria Monteleone
(AM)
Preben Mortensen
(P)
Melissa Munn-Chernoff
(M)
Benedetta Nacmias
(B)
Ida Nilsson
(I)
Claes Norring
(C)
Ioanna Ntalla
(I)
Julie O'Toole
(J)
Jacques Pantel
(J)
Hana Papezova
(H)
Richard Parker
(R)
Raquel Rabionet
(R)
Anu Raevuori
(A)
Andrzej Rajewski
(A)
Nicolas Ramoz
(N)
N William Rayner
(NW)
Ted Reichborn-Kjennerud
(T)
Valdo Ricca
(V)
Stephan Ripke
(S)
Franziska Ritschel
(F)
Marion Roberts
(M)
Alessandro Rotondo
(A)
Filip Rybakowski
(F)
Paolo Santonastaso
(P)
André Scherag
(A)
Ulrike Schmidt
(U)
Nicholas Schork
(N)
Alexandra Schosser
(A)
Jochen Seitz
(J)
Lenka Slachtova
(L)
P Eline Slagboom
(PE)
Margarita Slof-Op't Landt
(M)
Agnieszka Slopien
(A)
Tosha Smith
(T)
Sandro Sorbi
(S)
Eric Strengman
(E)
Michael Strober
(M)
Patrick Sullivan
(P)
Jin Szatkiewicz
(J)
Neonila Szeszenia-Dabrowska
(N)
Ioanna Tachmazidou
(I)
Elena Tenconi
(E)
Laura Thornton
(L)
Alfonso Tortorella
(A)
Federica Tozzi
(F)
Janet Treasure
(J)
Artemis Tsitsika
(A)
Konstantinos Tziouvas
(K)
Annemarie van Elburg
(A)
Eric van Furth
(E)
Tracey Wade
(T)
Gudrun Wagner
(G)
Esther Walton
(E)
Hunna Watson
(H)
D Blake Woodside
(DB)
Shuyang Yao
(S)
Zeynep Yilmaz
(Z)
Eleftheria Zeggini
(E)
Stephanie Zerwas
(S)
Stephan Zipfel
(S)
Lars Alfredsson
(L)
Ole Andreassen
(O)
Harald Aschauer
(H)
Jeffrey Barrett
(J)
Vladimir Bencko
(V)
Laura Carlberg
(L)
Sven Cichon
(S)
Sarah Cohen-Woods
(S)
Christian Dina
(C)
Bo Ding
(B)
Thomas Espeseth
(T)
James Floyd
(J)
Steven Gallinger
(S)
Giovanni Gambaro
(G)
Ina Giegling
(I)
Stefan Herms
(S)
Vladimir Janout
(V)
Antonio Julià
(A)
Lars Klareskog
(L)
Stephanie Le Hellard
(S)
Marion Leboyer
(M)
Astri Lundervold
(A)
Sara Marsal
(S)
Morten Mattingsdal
(M)
Marie Navratilova
(M)
Roel Ophoff
(R)
Aarno Palotie
(A)
Dalila Pinto
(D)
Samuli Ripatti
(S)
Dan Rujescu
(D)
Stephen Scherer
(S)
Laura Scott
(L)
Robert Sladek
(R)
Nicole Soranzo
(N)
Lorraine Southam
(L)
Vidar Steen
(V)
H-Erich Wichmann
(HE)
Elisabeth Widen
(E)
Gerome Breen
(G)
Cynthia Bulik
(C)
Informations de copyright
Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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