Base-pairing interactions between substrate RNA and H/ACA guide RNA modulate the kinetics of pseudouridylation, but not the affinity of substrate binding by H/ACA small nucleolar ribonucleoproteins.
Cbf5
H/ACA snoRNA
guide RNA
pseudouridine
ribonucleoprotein
Journal
RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
05
03
2019
accepted:
11
07
2019
pubmed:
18
7
2019
medline:
8
1
2020
entrez:
18
7
2019
Statut:
ppublish
Résumé
H/ACA small nucleolar ribonucleoproteins (snoRNPs) pseudouridylate RNA in eukaryotes and archaea. They target many RNAs site-specifically through base-pairing interactions between H/ACA guide and substrate RNA. Besides ribosomal RNA (rRNA) and small nuclear RNA (snRNA), H/ACA snoRNPs are thought to also modify messenger RNA (mRNA) with potential impacts on gene expression. However, the base pairing between known target RNAs and H/ACA guide RNAs varies widely in nature, and therefore the rules governing substrate RNA selection are still not fully understood. To provide quantitative insight into substrate RNA recognition, we systematically altered the sequence of a substrate RNA target by the
Identifiants
pubmed: 31311819
pii: rna.071043.119
doi: 10.1261/rna.071043.119
pmc: PMC6800473
doi:
Substances chimiques
RNA, Guide
0
Ribonucleoproteins, Small Nucleolar
0
Pseudouridine
1445-07-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1393-1404Informations de copyright
© 2019 Kelly et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.
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