Rapid identification of dragon blood samples from Daemonorops draco, Dracaena cinnabari and Dracaena cochinchinensis by MALDI-TOF mass spectrometry.
MALDI-TOF
dracorhodin
dragon blood
loureirin A
loureirin B
Journal
Phytochemical analysis : PCA
ISSN: 1099-1565
Titre abrégé: Phytochem Anal
Pays: England
ID NLM: 9200492
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
19
02
2019
revised:
27
04
2019
accepted:
14
05
2019
pubmed:
18
7
2019
medline:
18
2
2020
entrez:
18
7
2019
Statut:
ppublish
Résumé
Dragon blood is a deep-red plant resin which has been used as folk medicine for more than a thousand years. It can be produced from at least four entirely different plant families: Asparagaceae, Arecaceae, Chamaesyce, and Fabaceae. Current pharmacopeia states that the only "authentic" source of dragon blood is the palm tree, Daemonorops draco. The present study aims to find a high-throughput method to screen and identify the plant sources of commercial dragon blood products. A matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) based method for rapid screening of dracorhodin in commercial dragon blood samples was established in this study. Well-resolved peaks of dracorhodin in spectra were observed in the crude extracts of samples. Dragon blood samples from two other plant species, Dracaena cinnabari and Dracaena cochinchinensis, were also examined. Their indicator compounds, loureirin A and B, were detected in these plants. A MALDI-TOF based method for preliminarily examination of commercial dragon blood samples is reported here. In contrast to MALDI-TOF, liquid chromatography mass spectrometry (LC-MS) is a time-consuming and costly method, not ideal for routine and large-scale screening of commercial samples.
Substances chimiques
Plant Extracts
0
dragon's blood
M3YJ2C28IC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
720-726Informations de copyright
© 2019 John Wiley & Sons, Ltd.
Références
Gupta D, Bleakley B, Gupta RK. Dragon's blood: botany, chemistry and therapeutic uses. J Ethnopharmacol. 2008;115(3):361-380.
Namjoyan F, Kiashi F, Moosavi ZB, Saffari F, Makhmalzadeh BS. Efficacy of Dragon's blood cream on wound healing: a randomized, double-blind, placebo-controlled clinical trial. J Tradit Complement Med. 2015;6:37-40.
Pieters L, De Bruyne T, Van Poel B, et al. In vivo wound healing activity of Dragon's blood (Croton spp.), a traditional south American drug, and its constituents. Phytomedicine. 1995;2(1):17-22.
Department of Health, Hong Kong Special Administrative Region. Hong Kong Chinese Materia Medica strandards. 6 the People's Republic of China: Department of Health, Hong Kong Special Administrative Region; 2005:362-368.
State Pharmacopoeia Commission of the PRC. Pharmacopoeia of the People's Republic of China. 1: Beijing: People's Medical Publishing House; 2015:142.
Taiwan Herbal Pharmacopeia Editorial Panel Committee. Taiwan Herbal Pharmacopeia, version 2. Taipei: Ministry of Health and Welfare, Executive Yuan; 2013:102-103.
Jiang XW, Qiao L, Liu L, et al. Dracorhodin perchlorate accelerates cutaneous wound healing in wistar rats. Evid Based Complement Alternat Med. 2017;2017:8950516.
Krishnaraj P, Chang Y, Ho TJ, Lu NC, Lin MD, Chen HP. In vivo pro-angiogenic effects of dracorhodin perchlorate in zebrafish embryos: a novel bioactivity evaluation platform for commercial dragon blood samples. J Food Drug Anal. 2019;27(1):259-265.
Li F, Jiang T, Liu W, Hu Q, Yin H. The angiogenic effect of dracorhodin perchlorate on human umbilical vein endothelial cells and its potential mechanism of action. Mol Med Rep. 2016;14:1667e72.
Ho TJ, Jiung SJ, Lin GH, et al. The in vitro and in vivo wound healing properties of the Chinese herbal medicine “Jinchuang ointment”. Evid Based Complement Alternat Med. 2016;2016:1654056.
Qin JP, Wu JX, Li JC, Bi YA, Wang ZZ, Xiao W. Determination of five components in Draconis resina from different habitats by HPLC. Drugs & Clinic. 2013;28:547-549. in Chinese
Wallace WE, Arnould MA, Knochenmuss R. 2,5-Dihydroxybenzoic acid: laser desorption/ionization as a function of elevated temperature. Int J Mass Spectrom. 2005;242(1):13-22.
Fan JY, Yi T, Sze-To CM, et al. A systematic review of the botanical, phytochemical and pharmacological profile of Dracaena cochinchinensis, a plant source of the ethnomedicine “dragon's blood”. Molecules. 2014;19(7):10650-10669.
Deepika G, Bruce B, Rajinder KG. Dragon's blood: botany, chemistry and therapeutic uses. J Ethnopharmacol. 2008;115:361-380.
Lading A, Guo Y, Li L, Yu R, Si Y, Ding L. Comparing Chinese and foreign Resina draconis research. Guangdong Chem Ind. 2015;42:18-19. in Chinese