Molecular indicators of denervation in aging human skeletal muscle.
Aged
Aged, 80 and over
Aging
/ genetics
Humans
Male
Muscle Fibers, Skeletal
/ metabolism
Muscle, Skeletal
/ innervation
Myosin Heavy Chains
/ genetics
Neural Cell Adhesion Molecules
/ genetics
Quadriceps Muscle
/ innervation
RNA, Messenger
/ metabolism
Receptors, Cholinergic
/ genetics
Receptors, Nicotinic
/ genetics
acetylcholine receptor
denervation
human muscle
neonatal myosin
sarcopenia
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
24
01
2019
revised:
10
07
2019
accepted:
13
07
2019
pubmed:
18
7
2019
medline:
15
1
2020
entrez:
18
7
2019
Statut:
ppublish
Résumé
Muscle fiber denervation increases with age, yet studies at the tissue level are sparse due to the challenging nature of establishing the relative role of regeneration and denervation. Muscle biopsies were obtained from the vastus lateralis of 70 healthy men (aged 72 ± 6 years; range, 65-94). Messenger RNA (mRNA) levels of acetylcholine receptors (AchR) were measured, and sections were stained for embryonic myosin, neonatal myosin (MHC Embryonic myosin Muscle from healthy older individuals expressed developmental myosins to varying degrees but more than has been previously reported for young individuals. Along with the AchR correlations, we propose that these findings support the presence of neuromuscular junction destabilization, denervation, and reinnervation in aging human skeletal muscle.
Substances chimiques
CHRNG protein, human
0
Neural Cell Adhesion Molecules
0
RNA, Messenger
0
Receptors, Cholinergic
0
Receptors, Nicotinic
0
Myosin Heavy Chains
EC 3.6.4.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
453-463Informations de copyright
© 2019 Wiley Periodicals, Inc.
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