Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 07 2019
19 07 2019
Historique:
received:
03
01
2019
accepted:
05
06
2019
entrez:
21
7
2019
pubmed:
22
7
2019
medline:
18
12
2019
Statut:
epublish
Résumé
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.
Identifiants
pubmed: 31324762
doi: 10.1038/s41467-019-10884-9
pii: 10.1038/s41467-019-10884-9
pmc: PMC6642170
doi:
Substances chimiques
Anti-HIV Agents
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3193Investigateurs
Alexia Anagnostopoulos
(A)
Manuel Battegay
(M)
Enos Bernasconi
(E)
Jürg Böni
(J)
Dominique L Braun
(DL)
Heiner C Bucher
(HC)
Alexandra Calmy
(A)
Matthias Cavassini
(M)
Angela Ciuffi
(A)
Günter Dollenmaier
(G)
Matthias Egger
(M)
Luigia Elzi
(L)
Jan Fehr
(J)
Jacques Fellay
(J)
Hansjakob Furrer
(H)
Christoph A Fux
(CA)
Huldrych F Günthard
(HF)
David Haerry
(D)
Barbara Hasse
(B)
Hans H Hirsch
(HH)
Matthias Hoffmann
(M)
Irene Hösli
(I)
Michael Huber
(M)
Christian Kahlert
(C)
Laurent Kaiser
(L)
Olivia Keiser
(O)
Thomas Klimkait
(T)
Roger D Kouyos
(RD)
Helen Kovari
(H)
Bruno Ledergerber
(B)
Gladys Martinetti
(G)
Begona Martinez de Tejada
(BM)
Catia Marzolini
(C)
Karin J Metzner
(KJ)
Nicolas Müller
(N)
Dunja Nicca
(D)
Paolo Paioni
(P)
Guiseppe Pantaleo
(G)
Matthieu Perreau
(M)
Andri Rauch
(A)
Christoph Rudin
(C)
Alexandra U Scherrer
(AU)
Patrick Schmid
(P)
Roberto Speck
(R)
Marcel Stöckle
(M)
Philip Tarr
(P)
Alexandra Trkola
(A)
Pietro Vernazza
(P)
Gilles Wandeler
(G)
Rainer Weber
(R)
Sabine Yerly
(S)
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