Molecular mechanism of setron-mediated inhibition of full-length 5-HT

Animals Antiemetics / pharmacology Binding Sites Brain Stem Cryoelectron Microscopy Gastrointestinal Tract Ligands Models, Molecular Molecular Docking Simulation Molecular Dynamics Simulation Mutation Receptors, Serotonin, 5-HT3 / drug effects Serotonin / pharmacology Serotonin 5-HT3 Receptor Antagonists / pharmacology Xenopus laevis / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
19 07 2019
Historique:
received: 21 02 2019
accepted: 23 06 2019
entrez: 21 7 2019
pubmed: 22 7 2019
medline: 18 12 2019
Statut: epublish

Résumé

Serotonin receptor (5-HT

Identifiants

DOI: 10.1038/s41467-019-11142-8 PMID: 31324772 PMC: PMC6642186
pubmed: 31324772
doi: 10.1038/s41467-019-11142-8
pii: 10.1038/s41467-019-11142-8
pmc: PMC6642186
doi:

Substances chimiques

Antiemetics 0
Ligands 0
Receptors, Serotonin, 5-HT3 0
Serotonin 5-HT3 Receptor Antagonists 0
Serotonin 333DO1RDJY

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3225

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM108921
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM131216
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM134896
Pays : United States
Organisme : NIH HHS
ID : S10 OD018522
Pays : United States

Références

Nat Methods. 2014 Jan;11(1):63-5
pubmed: 24213166
EMBO Rep. 2013 Jan;14(1):49-56
pubmed: 23196367
J Biol Chem. 1999 Feb 26;274(9):5537-41
pubmed: 10026168
Curr Opin Pharmacol. 2011 Feb;11(1):68-74
pubmed: 21398180
IUCrJ. 2019 Jan 01;6(Pt 1):5-17
pubmed: 30713699
J Phys Chem B. 1998 Apr 30;102(18):3586-616
pubmed: 24889800
J Chem Phys. 2015 Nov 7;143(17):174101
pubmed: 26547152
J Comput Chem. 2008 Aug;29(11):1859-65
pubmed: 18351591
Biochemistry. 2002 Aug 13;41(32):10262-9
pubmed: 12162741
Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54
pubmed: 12393927
Nat Neurosci. 2002 Nov;5(11):1163-8
pubmed: 12368804
Curr Drug Targets CNS Neurol Disord. 2004 Feb;3(1):27-37
pubmed: 14965242
Mol Pharmacol. 2005 Aug;68(2):365-71
pubmed: 15914697
Cancer Manag Res. 2018 Jul 03;10:1827-1857
pubmed: 30013391
J Chem Theory Comput. 2015 Nov 10;11(11):5525-42
pubmed: 26574340
ACS Chem Neurosci. 2016 Dec 21;7(12):1641-1646
pubmed: 27656911
Biochemistry. 2006 Jan 31;45(4):1099-105
pubmed: 16430206
J Comput Chem. 2005 Dec;26(16):1701-18
pubmed: 16211538
Nature. 2018 Nov;563(7730):270-274
pubmed: 30401837
Acta Crystallogr D Biol Crystallogr. 1994 Sep 1;50(Pt 5):760-3
pubmed: 15299374
J Recept Signal Transduct Res. 2003;23(2-3):255-70
pubmed: 14626451
J Biol Chem. 2009 Jun 5;284(23):15847-56
pubmed: 19286654
J Biol Chem. 2005 May 27;280(21):20476-82
pubmed: 15781467
Nature. 2019 Jan;565(7740):454-459
pubmed: 30602790
J Mol Graph. 1996 Dec;14(6):354-60, 376
pubmed: 9195488
J Biol Chem. 2012 Nov 23;287(48):40239-45
pubmed: 23038271
Front Cell Neurosci. 2013 May 27;7:76
pubmed: 23761731
Am J Ther. 2010 Sep-Oct;17(5):476-86
pubmed: 20844345
J Mol Graph. 1996 Feb;14(1):33-8, 27-8
pubmed: 8744570
J Comput Chem. 2010 Mar;31(4):671-90
pubmed: 19575467
EMBO J. 2009 Oct 7;28(19):3040-51
pubmed: 19696737
Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):12-21
pubmed: 20057044
Br J Pharmacol. 2003 Sep;140(2):359-65
pubmed: 12970096
Neuropharmacology. 2017 Jun;119:48-61
pubmed: 28137449
Nature. 2014 Aug 21;512(7514):276-81
pubmed: 25119048
Nat Commun. 2018 Feb 6;9(1):514
pubmed: 29410406
Phys Rev A Gen Phys. 1985 Mar;31(3):1695-1697
pubmed: 9895674
Neuropharmacology. 2013 Oct;73:241-6
pubmed: 23747573
Science. 1991 Oct 18;254(5030):432-7
pubmed: 1718042
J Chem Theory Comput. 2016 Jun 14;12(6):2990-8
pubmed: 27145262
Nature. 2015 Oct 8;526(7572):224-9
pubmed: 26344198
Bioorg Med Chem Lett. 2001 Feb 12;11(3):319-21
pubmed: 11212100
J Biol Chem. 2000 Feb 25;275(8):5620-5
pubmed: 10681544
Neuroreport. 1995 Jan 26;6(2):257-61
pubmed: 7756605
Aliment Pharmacol Ther. 2004 Nov;20 Suppl 7:3-14
pubmed: 15521849
Nature. 2018 Nov;563(7730):275-279
pubmed: 30401839
Expert Opin Ther Targets. 2007 Apr;11(4):527-40
pubmed: 17373882
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
Biochemistry. 1984 Dec 18;23(26):6544-9
pubmed: 6529569
Ther Clin Risk Manag. 2007 Dec;3(6):1009-20
pubmed: 18516316
J Gen Physiol. 2013 Apr;141(4):467-78
pubmed: 23478996
Neurosci Lett. 2005 Apr 22;378(3):140-4
pubmed: 15781147
J Struct Biol. 2003 Jun;142(3):334-47
pubmed: 12781660
Biochemistry. 2014 Sep 30;53(38):6041-51
pubmed: 25184435
Nat Methods. 2017 Apr;14(4):331-332
pubmed: 28250466
Acta Crystallogr D Struct Biol. 2017 Jun 1;73(Pt 6):496-502
pubmed: 28580911
J Chem Theory Comput. 2012 Sep 11;8(9):3257-3273
pubmed: 23341755
J Biol Chem. 2006 Jun 16;281(24):16576-82
pubmed: 16595668
ACS Chem Biol. 2012 Oct 19;7(10):1738-45
pubmed: 22873819
EMBO J. 2005 Oct 19;24(20):3635-46
pubmed: 16193063
J Chem Phys. 2007 Jan 7;126(1):014101
pubmed: 17212484
Curr Pharm Des. 2006;12(28):3615-30
pubmed: 17073663
Nat Methods. 2017 Jan;14(1):71-73
pubmed: 27819658

Auteurs

Sandip Basak (S)

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.
ORCID: 0000-0003-4018-8020

Yvonne Gicheru (Y)

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.

Abhijeet Kapoor (A)

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Megan L Mayer (ML)

Division of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA, 94025, USA.

Marta Filizola (M)

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-4382-8276

Sudha Chakrapani (S)

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106-4970, USA. Sudha.chakrapani@case.edu.
Department of Neuroscience, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106-4970, USA. Sudha.chakrapani@case.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents gastro-intestinaux › Antiémétiques › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Système digestif › Tube digestif › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs sérotoninergiques › Récepteurs sérotoninergiques 5-HT3 › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents sérotoninergiques › Antisérotonines › Antagonistes des récepteurs 5-HT3 de la sérotonine › Molecular mechanism of setron-mediated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Pipidae › Xenopus › Xenopus laevis › Molecular mechanism of setron-mediated...