Trypanosoma brucei brucei causes a rapid and persistent influx of neutrophils in the spleen of infected mice.
Trypanosoma spp.
cell-mediated immunity
neutrophil
Journal
Parasite immunology
ISSN: 1365-3024
Titre abrégé: Parasite Immunol
Pays: England
ID NLM: 7910948
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
29
05
2019
revised:
29
06
2019
accepted:
16
07
2019
pubmed:
22
7
2019
medline:
3
3
2020
entrez:
21
7
2019
Statut:
ppublish
Résumé
Trypanosomosis is a chronic parasitic infection, affecting both humans and livestock. A common hallmark of experimental murine infections is the occurrence of inflammation and the associated remodelling of the spleen compartment. The latter involves the depletion of several lymphocyte populations, the induction of T-cell-mediated immune suppression, and the activation of monocyte/macrophage cell populations. Here, we show that in experimental T b brucei infections in mice, these changes are accompanied by the alteration of the spleen neutrophil compartment. Indeed, mature neutrophils are rapidly recruited to the spleen, and cell numbers remain elevated during the entire infection. Following the second peak of parasitemia, the neutrophil cell influx coincides with the rapid reduction of splenic marginal zone (MZ)B and follicular (Fo)B cells, as well as CD8
Identifiants
pubmed: 31325372
doi: 10.1111/pim.12664
pmc: PMC6771705
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12664Informations de copyright
© 2019 The Authors. Parasite Immunology published by John Wiley & Sons Ltd.
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