Neurite orientation dispersion and density imaging for evaluating the severity of neonatal hypoxic-ischemic encephalopathy in rats.
Animals
Animals, Newborn
Anisotropy
Cerebral Cortex
/ diagnostic imaging
Cerebrovascular Circulation
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Gray Matter
/ diagnostic imaging
Humans
Hypoxia-Ischemia, Brain
/ diagnostic imaging
Male
Neurites
/ metabolism
Rats
Rats, Wistar
White Matter
/ diagnostic imaging
Diffusion tensor imaging
Hypoxic-ischemic encephalopathy
Magnetic resonance imaging
Neurite orientation dispersion and density imaging
Journal
Magnetic resonance imaging
ISSN: 1873-5894
Titre abrégé: Magn Reson Imaging
Pays: Netherlands
ID NLM: 8214883
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
13
05
2019
revised:
27
06
2019
accepted:
17
07
2019
pubmed:
22
7
2019
medline:
3
1
2020
entrez:
21
7
2019
Statut:
ppublish
Résumé
To evaluate the utility of neurite orientation dispersion and density imaging (NODDI) for longitudinally assessing neonatal hypoxic-ischemic (HI) encephalopathy severity with 7.0 T magnetic resonance imaging. Thirteen 8-day-old Wistar rats underwent unilateral ligation of the left common carotid artery followed by mild (1 h; n = 6) or severe (2 h; n = 7) hypoxic exposure (8% O Left hemisphere brain damage was identified as slight hyperintensity on T Here, ODI, a NODDI metric, identified early differences between mild and severe HI injuries. Our findings support the potential utility of NODDI for determining neonatal HI encephalopathy severity in rats.
Identifiants
pubmed: 31325487
pii: S0730-725X(19)30305-4
doi: 10.1016/j.mri.2019.07.013
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
214-219Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.