Association of Asymmetric Dimethylarginine and Diastolic Dysfunction in Patients with Hypertrophic Cardiomyopathy.
arginine derivatives
biomarker
diastolic dysfunction
hypertrophic cardiomyopathy
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
13 07 2019
13 07 2019
Historique:
received:
07
06
2019
revised:
11
07
2019
accepted:
11
07
2019
entrez:
25
7
2019
pubmed:
25
7
2019
medline:
9
4
2020
Statut:
epublish
Résumé
Despite genetic heterogeneity, early manifestation of diastolic dysfunction (DD) is common in hypertrophic cardiomyopathy (HCM). Nitric oxide (NO) may contribute to myocardial relaxation. NO synthases (NOS) use l-arginine (Arg) as a substrate, as asymmetric dimethylarginine (ADMA) is a direct endogenous inhibitor of NOS. This study aimed to analyze the association of Arg and its derivates, i.e., l-homoarginine (hArg), ADMA and symmetric dimethylarginine (SDMA), with DD in HCM patients. In 215 HCM patients (mean age 54 ± 15 years, 58% male) transmitral and mitral annulus velocities were echocardiographically analyzed. Plasma concentrations of Arg derivatives were measured by liquid chromatography tandem-mass spectrometry. In 143 (70%) patients suffering from DD, ADMA showed the strongest association with DD (0.66 ± 0.16, 0.72 ± 0.24, and 0.76 ± 0.26 µmol/L,
Identifiants
pubmed: 31337005
pii: biom9070277
doi: 10.3390/biom9070277
pmc: PMC6681289
pii:
doi:
Substances chimiques
N,N-dimethylarginine
63CV1GEK3Y
Arginine
94ZLA3W45F
Nitric Oxide Synthase
EC 1.14.13.39
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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