Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection.
Animals
Blood Platelets
/ metabolism
Chemokine CXCL10
/ metabolism
Coxsackievirus Infections
/ immunology
Disease Models, Animal
Enterovirus B, Human
/ immunology
Female
Fibroblasts
/ immunology
Genome, Viral
Immunoglobulin G
/ immunology
Inflammation Mediators
/ metabolism
Influenza A Virus, H1N1 Subtype
/ immunology
Lung Diseases
/ immunology
Macrophages
/ immunology
Male
Mice
Mice, Inbred C57BL
Myocarditis
/ immunology
Orthomyxoviridae Infections
/ immunology
Receptors, Thrombin
/ deficiency
Spleen
/ cytology
Virus Replication
Influenza
Innate immune responses
Myocarditis
Protease-activated receptor 4
Journal
Cellular immunology
ISSN: 1090-2163
Titre abrégé: Cell Immunol
Pays: Netherlands
ID NLM: 1246405
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
29
01
2019
revised:
20
06
2019
accepted:
02
07
2019
pubmed:
25
7
2019
medline:
9
6
2020
entrez:
25
7
2019
Statut:
ppublish
Résumé
PAR4 is expressed by a variety of cells, including platelets, cardiac, lung and immune cells. We investigated the contribution of PAR4 to viral infections of the heart and lung. Toll-like receptor (TLR) 3-dependent immune responses were analyzed after co-stimulation of PAR4 in murine bone-marrow derived macrophages, embryonic fibroblasts and embryonic cardiomyocytes. In addition, we analyzed Coxsackievirus B3 (CVB3) or H1N1 influenza A virus (H1N1 IAV) infection of PAR4
Identifiants
pubmed: 31337508
pii: S0008-8749(19)30037-1
doi: 10.1016/j.cellimm.2019.103949
pmc: PMC6739161
mid: NIHMS1535337
pii:
doi:
Substances chimiques
Chemokine CXCL10
0
Cxcl10 protein, mouse
0
Immunoglobulin G
0
Inflammation Mediators
0
Receptors, Thrombin
0
protease-activated receptor 4
JWE1M73YZN
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
103949Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL119523
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142799
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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