Examination of attention, executive function, and memory as predictors of mortality risk in adults with systolic heart failure.
Heart failure
cognitive function
mortality
risk assessment
Journal
European journal of cardiovascular nursing
ISSN: 1873-1953
Titre abrégé: Eur J Cardiovasc Nurs
Pays: England
ID NLM: 101128793
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
pubmed:
26
7
2019
medline:
18
8
2020
entrez:
26
7
2019
Statut:
ppublish
Résumé
The prevalence and impact of cognitive impairment in heart failure is increasingly recognized. Converging evidence points to global cognitive function as predictive of prognosis in adults with heart failure when assessed with screening tools. Additional work is needed to understand which domains of cognitive function are most relevant for prognosis. The present study sought to examine associations between domains of cognitive function and mortality risk in adults with heart failure. In the present prospective, observational cohort study, global cognitive function, attention, executive function, and memory were assessed by means of a comprehensive neuropsychogical battery in adults with systolic heart failure. Mortality data were obtained from the National Death Index (median follow-up 2.95 years). Relationships among each cognitive domain and mortality were assessed with Cox regression. Covariates included age, sex, heart failure severity, comorbidity and depressive symptoms. Participants were 325 patients with systolic heart failure with a mean age of 68.6 years (59% men, 73% Caucasian). Following covariate adjustment, better global cognitive function, attention, and executive function were related to decreased mortality risk. Future research is needed to clarify the underlying mechanisms of the association between cognitive impairment and mortality.
Sections du résumé
BACKGROUND
The prevalence and impact of cognitive impairment in heart failure is increasingly recognized. Converging evidence points to global cognitive function as predictive of prognosis in adults with heart failure when assessed with screening tools. Additional work is needed to understand which domains of cognitive function are most relevant for prognosis.
AIMS
The present study sought to examine associations between domains of cognitive function and mortality risk in adults with heart failure.
METHODS
In the present prospective, observational cohort study, global cognitive function, attention, executive function, and memory were assessed by means of a comprehensive neuropsychogical battery in adults with systolic heart failure. Mortality data were obtained from the National Death Index (median follow-up 2.95 years). Relationships among each cognitive domain and mortality were assessed with Cox regression. Covariates included age, sex, heart failure severity, comorbidity and depressive symptoms.
RESULTS
Participants were 325 patients with systolic heart failure with a mean age of 68.6 years (59% men, 73% Caucasian). Following covariate adjustment, better global cognitive function, attention, and executive function were related to decreased mortality risk.
CONCLUSIONS
Future research is needed to clarify the underlying mechanisms of the association between cognitive impairment and mortality.
Identifiants
pubmed: 31342781
doi: 10.1177/1474515119863182
pmc: PMC6916714
mid: NIHMS1059666
doi:
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
729-735Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL096710
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL076134
Pays : United States
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