Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.


Journal

Experimental gerontology
ISSN: 1873-6815
Titre abrégé: Exp Gerontol
Pays: England
ID NLM: 0047061

Informations de publication

Date de publication:
01 10 2019
Historique:
received: 14 01 2019
revised: 14 07 2019
accepted: 20 07 2019
pubmed: 26 7 2019
medline: 17 7 2020
entrez: 26 7 2019
Statut: ppublish

Résumé

Mitochondrial DNA (mtDNA) mutations are thought to have a causal role in a variety of age-related neurodegenerative diseases, including age-related hearing loss (AHL). In the current study, we investigated the roles of mtDNA deletions and point mutations in AHL in mitochondrial mutator mice (Polg

Identifiants

pubmed: 31344454
pii: S0531-5565(19)30035-X
doi: 10.1016/j.exger.2019.110675
pmc: PMC6857812
mid: NIHMS1536253
pii:
doi:

Substances chimiques

DNA, Mitochondrial 0
DNA Polymerase gamma EC 2.7.7.7
Polg protein, mouse EC 2.7.7.7

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

110675

Subventions

Organisme : NIDCD NIH HHS
ID : R01 DC012552
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055518
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028748
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014437
Pays : United States
Organisme : NIA NIH HHS
ID : K08 AG032873
Pays : United States
Organisme : NIDCD NIH HHS
ID : R03 DC011840
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Mi-Jung Kim (MJ)

Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.

Suraiya Haroon (S)

Center for Mitochondrial and Epigenomic Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Guang-Di Chen (GD)

Center for Hearing and Deafness, State University of New York at Buffalo, NY, USA.

Dalian Ding (D)

Center for Hearing and Deafness, State University of New York at Buffalo, NY, USA.

Jonathan Wanagat (J)

Department of Medicine, University of California, Los Angeles, CA, USA.

Lijie Liu (L)

Center for Hearing and Deafness, State University of New York at Buffalo, NY, USA.

Yanping Zhang (Y)

Gene Expression & Genotyping, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL, USA.

Karessa White (K)

Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.

Hyo-Jin Park (HJ)

Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.

Chul Han (C)

Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.

Kevin Boyd (K)

Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.

Isabela Caicedo (I)

Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.

Kaitlyn Evans (K)

Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.

Paul J Linser (PJ)

Whitney Laboratory, University of Florida, St Augustine, FL, USA.

Masaru Tanokura (M)

Department of Applied Biological Chemistry, University of Tokyo, Yayoi, Tokyo, Japan.

Tomas Prolla (T)

Department of Genetics, University of Wisconsin, Madison, WI, USA.

Richard Salvi (R)

Center for Hearing and Deafness, State University of New York at Buffalo, NY, USA; Department of Audiology and Speech-Language Pathology, Asia University, Taichung, Taiwan, ROC.

Marc Vermulst (M)

Center for Mitochondrial and Epigenomic Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Shinichi Someya (S)

Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA. Electronic address: someya@ufl.edu.

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Classifications MeSH