The Changing Clinical Spectrum of Hypophysitis.

Hormone Replacement Therapy / methods Humans Hypophysitis / diagnosis Immunosuppressive Agents / therapeutic use Pituitary Gland / drug effects
autoimmune diabetes insipidus hypopituitarism immunotherapy ipilimumab pituitary

Journal

Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516

Informations de publication

Date de publication:
09 2019
Historique:
received: 30 04 2019
revised: 16 06 2019
accepted: 21 06 2019
pubmed: 28 7 2019
medline: 28 7 2020
entrez: 27 7 2019
Statut: ppublish

Résumé

Hypophysitis is a rare and potentially life-threatening disease, characterized by an elevated risk of complications, such as occurrence of acute central hypoadrenalism, persistent hypopituitarism, or extension of the inflammatory process to the neighboring neurological structures. In recent years, a large number of patients have been described as being affected by hypophysitis, due to the increased administration of immuno-chemotherapies. At the present time, the heterogeneous nature of hypophysitis diagnostic criteria and of the treatment protocols makes the management of affected patients difficult. We review the current data and evidence on primary and secondary hypophysitis, in order to suggest a diagnostic and therapeutic protocol that should be focused on a multidisciplinary approach, for reaching a prompt diagnosis and an appropriate and safe treatment.

Identifiants

DOI: 10.1016/j.tem.2019.06.004 PMID: 31345630
pubmed: 31345630
pii: S1043-2760(19)30121-3
doi: 10.1016/j.tem.2019.06.004
pii:
doi:

Substances chimiques

Immunosuppressive Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

590-602

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Sabrina Chiloiro (S)

Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Ettore Domenico Capoluongo (ED)

Department of Molecular Medicine, Università Federico II, Naple, Italy.

Tommaso Tartaglione (T)

Department of Radiology, Istituto Dermopatico dell'Immacolata, Rome and Università Cattolica del Sacro Cuore, Rome, Italy.

Antonella Giampietro (A)

Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Antonio Bianchi (A)

Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Andrea Giustina (A)

Department of Endocrinology, Università Vita Salute San Raffaele, Milan, Italy.

Alfredo Pontecorvi (A)

Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Laura De Marinis (L)

Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: Laura.DeMarinis@unicatt.it.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Hormonothérapie substitutive › The Changing Clinical Spectrum of Hypophysitis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Changing Clinical Spectrum of Hypophysitis.
questionsmedicales.fr › Maladies endocriniennes › Maladies de l'hypophyse › Hypophysite › The Changing Clinical Spectrum of Hypophysitis.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › The Changing Clinical Spectrum of Hypophysitis.
questionsmedicales.fr › Système nerveux › Système neuroendocrinien › Axe hypothalamohypophysaire › Hypophyse › The Changing Clinical Spectrum of Hypophysitis.