Genetic diversity of HLA system in two populations from Yucatán, Mexico: Mérida and rural Yucatán.
Admixture
HLA
Immunogenetics
Population genetics
Yucatán
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
08
07
2019
accepted:
11
07
2019
pubmed:
28
7
2019
medline:
17
6
2021
entrez:
27
7
2019
Statut:
ppublish
Résumé
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 324 Mexicans from the state of Yucatán living in the city of Mérida (N = 192) and rural communities (N = 132), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in the state of Yucatán include 16 Native American and one European haplotype. Admixture estimates revealed that the main genetic components in Yucatán are Native American (81.54 ± 4.99% by ML; 62.92% of Native American haplotypes) and European (11.50 ± 15.43% by ML; 23.26% of European haplotypes), and a less prominent African genetic component (6.96 ± 10.47% by ML; 5.93% of African haplotypes).
Identifiants
pubmed: 31345700
pii: S0198-8859(19)30968-1
doi: 10.1016/j.humimm.2019.07.280
pii:
doi:
Substances chimiques
HLA Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
569-572Informations de copyright
Copyright © 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.