Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis.

Adult Aged Antibodies, Monoclonal / therapeutic use Bestrophins / metabolism CD8 Antigens / metabolism Case-Control Studies Colitis, Ulcerative / drug therapy Colon / metabolism Enterocytes / cytology Female Genetic Loci Genome-Wide Association Study Humans Interleukin-17 / metabolism Male Middle Aged Risk Factors T-Lymphocytes / cytology Thrombospondins / metabolism Tumor Necrosis Factor-alpha / immunology Young Adult
anti-TNF resistance cell-cell interactions colon genome-wide association studies inflammation inflammatory bowel disease large intestine single-cell RNA-seq single-cell genomics ulcerative colitis

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
25 07 2019
Historique:
received: 27 09 2018
revised: 25 03 2019
accepted: 18 06 2019
entrez: 27 7 2019
pubmed: 28 7 2019
medline: 28 4 2020
Statut: ppublish

Résumé

Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis (UC). To understand their cell type specificities and pathways of action, we generate an atlas of 366,650 cells from the colon mucosa of 18 UC patients and 12 healthy individuals, revealing 51 epithelial, stromal, and immune cell subsets, including BEST4

Identifiants

DOI: 10.1016/j.cell.2019.06.029 PMID: 31348891 PMC: PMC6662628
pubmed: 31348891
pii: S0092-8674(19)30732-9
doi: 10.1016/j.cell.2019.06.029
pmc: PMC6662628
mid: NIHMS1532849
pii:
doi:

Substances chimiques

Antibodies, Monoclonal 0
BEST4 protein, human 0
Bestrophins 0
CD8 Antigens 0
Interleukin-17 0
RSPO3 protein, human 0
Thrombospondins 0
Tumor Necrosis Factor-alpha 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

714-730.e22

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK043351
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117263
Pays : United States
Organisme : NHGRI NIH HHS
ID : P50 HG006193
Pays : United States
Organisme : NIAID NIH HHS
ID : U24 AI118672
Pays : United States
Organisme : NHGRI NIH HHS
ID : RM1 HG006193
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK114379
Pays : United States
Organisme : NIDDK NIH HHS
ID : RC2 DK114784
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Christopher S Smillie (CS)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Moshe Biton (M)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA; Department of Molecular Biology, MGH, Boston, MA, USA.

Jose Ordovas-Montanes (J)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA; Institute for Medical Engineering and Science (IMES), MIT, Cambridge, MA, USA; Department of Chemistry, MIT, Cambridge, MA, USA; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Division of Infectious Diseases and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.

Keri M Sullivan (KM)

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA.

Grace Burgin (G)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Daniel B Graham (DB)

Department of Molecular Biology, MGH, Boston, MA, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA; Broad Institute, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.

Rebecca H Herbst (RH)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.

Noga Rogel (N)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Michal Slyper (M)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Julia Waldman (J)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Malika Sud (M)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Elizabeth Andrews (E)

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA.

Gabriella Velonias (G)

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA.

Adam L Haber (AL)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Karthik Jagadeesh (K)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Sanja Vickovic (S)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Junmei Yao (J)

Center for Computational and Integrative Biology, MGH, Boston, MA, USA.

Christine Stevens (C)

Broad Institute, Cambridge, MA, USA.

Danielle Dionne (D)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Lan T Nguyen (LT)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Alexandra-Chloé Villani (AC)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA; Center for Immunology and Inflammatory Diseases, Department of Medicine, MGH, Boston, MA, USA.

Matan Hofree (M)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

Elizabeth A Creasey (EA)

Center for Computational and Integrative Biology, MGH, Boston, MA, USA.

Hailiang Huang (H)

Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Analytical and Translational Genetics Unit, MGH, Boston, MA, USA.

Orit Rozenblatt-Rosen (O)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA.

John J Garber (JJ)

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA.

Hamed Khalili (H)

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA.

A Nicole Desch (AN)

Broad Institute, Cambridge, MA, USA; Center for Computational and Integrative Biology, MGH, Boston, MA, USA.

Mark J Daly (MJ)

Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Analytical and Translational Genetics Unit, MGH, Boston, MA, USA; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

Ashwin N Ananthakrishnan (AN)

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA. Electronic address: aananthakrishnan@mgh.harvard.edu.

Alex K Shalek (AK)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA; Institute for Medical Engineering and Science (IMES), MIT, Cambridge, MA, USA; Department of Chemistry, MIT, Cambridge, MA, USA; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. Electronic address: shalek@mit.edu.

Ramnik J Xavier (RJ)

Department of Molecular Biology, MGH, Boston, MA, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA; Broad Institute, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA; Center for Computational and Integrative Biology, MGH, Boston, MA, USA. Electronic address: xavier@molbio.mgh.harvard.edu.

Aviv Regev (A)

Klarman Cell Observatory, Broad Institute, Cambridge, MA, USA; Howard Hughes Medical Institute and Koch Institute for Integrative Cancer Research, Department of Biology, MIT, Cambridge, MA, USA. Electronic address: aregev@broadinstitute.org.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux chlorure › Bestrophines › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD8 › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Rectocolite hémorragique › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Côlon › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Cellules › Cellules épithéliales › Entérocytes › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-17 › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Thrombospondines › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › Intra- and Inter-cellular Rewiring of the...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Intra- and Inter-cellular Rewiring of the...