Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies.
depressive symptoms
individual participant data (IPD) meta-analysis
subclinical hyperthyroidism
subclinical hypothyroidism
subclinical thyroid dysfunction
systematic review
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
26 07 2019
26 07 2019
Historique:
entrez:
28
7
2019
pubmed:
28
7
2019
medline:
15
8
2020
Statut:
epublish
Résumé
Prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms have yielded conflicting findings, possibly because of differences in age, sex, thyroid-stimulating hormone cut-off levels or degree of baseline depressive symptoms. Analysis of individual participant data (IPD) may help clarify this association. We will conduct a systematic review and IPD meta-analysis of prospective studies on the association between subclinical thyroid dysfunction and depressive symptoms. We will identify studies through a systematic search of the literature in the Ovid Medline, Ovid Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases from inception to April 2019 and from the Thyroid Studies Collaboration. We will ask corresponding authors of studies that meet our inclusion criteria to collaborate by providing IPD. Our primary outcome will be depressive symptoms at the first available individual follow-up, measured on a validated scale. We will convert all the scores to the Beck Depression Inventory scale. For each cohort, we will estimate the mean difference of depressive symptoms between participants with subclinical hypothyroidism or hyperthyroidism and control adjusted for depressive symptoms at baseline. Furthermore, we will adjust our multivariable linear regression analyses for age, sex, education and income. We will pool the effect estimates of all studies in a random-effects meta-analysis. Heterogeneity will be assessed by I Formal ethical approval is not required as primary data will not be collected. Our findings will have considerable implications for patient care. We will seek to publish this systematic review and IPD meta-analysis in a high-impact clinical journal. CRD42018091627.
Identifiants
pubmed: 31350252
pii: bmjopen-2019-029716
doi: 10.1136/bmjopen-2019-029716
pmc: PMC6661665
doi:
Substances chimiques
Thyroid Hormones
0
Thyrotropin
9002-71-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e029716Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
PLoS One. 2018 Aug 14;13(8):e0202258
pubmed: 30106989
Arch Gerontol Geriatr. 2007 Jan-Feb;44(1):21-8
pubmed: 16678286
JAMA. 2010 Sep 22;304(12):1365-74
pubmed: 20858880
JAMA. 2015 May 26;313(20):2055-65
pubmed: 26010634
PLoS One. 2016 May 16;11(5):e0155431
pubmed: 27182821
PLoS One. 2018 Apr 30;13(4):e0196631
pubmed: 29709030
JAMA. 2015 Apr 28;313(16):1657-65
pubmed: 25919529
J Clin Endocrinol Metab. 2018 May 1;103(5):1827-1833
pubmed: 29408972
Stat Med. 2013 Jul 20;32(16):2747-66
pubmed: 23303608
J Clin Endocrinol Metab. 2018 May 1;103(5):2061-2064
pubmed: 29481656
Neuroendocrinology. 2016;103(3-4):291-9
pubmed: 26202797
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
J Evid Based Med. 2015 Feb;8(1):2-10
pubmed: 25594108
Circulation. 2017 Nov 28;136(22):2100-2116
pubmed: 29061566