In situ structures of RNA-dependent RNA polymerase inside bluetongue virus before and after uncoating.

Bluetongue virus / enzymology Models, Molecular Protein Binding Protein Conformation RNA-Dependent RNA Polymerase / metabolism Structural Homology, Protein Viral Proteins / chemistry Virion / ultrastructure Virus Uncoating / physiology
RNA-dependent RNA polymerase cryoEM dsRNA virus reovirus transcription

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
13 08 2019
Historique:
pubmed: 28 7 2019
medline: 26 3 2020
entrez: 28 7 2019
Statut: ppublish

Résumé

Bluetongue virus (BTV), a major threat to livestock, is a multilayered, nonturreted member of the

Identifiants

DOI: 10.1073/pnas.1905849116 PMID: 31350350 PMC: PMC6697807
pubmed: 31350350
pii: 1905849116
doi: 10.1073/pnas.1905849116
pmc: PMC6697807
doi:

Substances chimiques

Viral Proteins 0
RNA-Dependent RNA Polymerase EC 2.7.7.48

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

16535-16540

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI094386
Pays : United States
Organisme : NIH HHS
ID : S10 OD018111
Pays : United States
Organisme : NIGMS NIH HHS
ID : U24 GM116792
Pays : United States
Organisme : Wellcome Trust
ID : 100218
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI045000
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Références

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Auteurs

Yao He (Y)

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095.
California NanoSystems Institute, University of California, Los Angeles, CA 90095.
ORCID: 0000-0002-1368-6422

Sakar Shivakoti (S)

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095.
California NanoSystems Institute, University of California, Los Angeles, CA 90095.

Ke Ding (K)

California NanoSystems Institute, University of California, Los Angeles, CA 90095.
ORCID: 0000-0002-0115-5931

Yanxiang Cui (Y)

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095.
California NanoSystems Institute, University of California, Los Angeles, CA 90095.

Polly Roy (P)

Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, WC1E 7HT London, United Kingdom.

Z Hong Zhou (ZH)

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095; Hong.Zhou@UCLA.edu.
California NanoSystems Institute, University of California, Los Angeles, CA 90095.
ORCID: 0000-0002-8373-4717

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Classifications MeSH

questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN double brin › Reoviridae › Orbivirus › Virus de la langue bleue › In situ structures of RNA-dependent RNA...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › In situ structures of RNA-dependent RNA...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › In situ structures of RNA-dependent RNA...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › In situ structures of RNA-dependent RNA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA replicase › In situ structures of RNA-dependent RNA...
questionsmedicales.fr › Phénomènes génétiques › Similitude structurale de protéines › In situ structures of RNA-dependent RNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › In situ structures of RNA-dependent RNA...
questionsmedicales.fr › Structures virales › Virion › In situ structures of RNA-dependent RNA...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Décapsidation virale › In situ structures of RNA-dependent RNA...