Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
26 07 2019
26 07 2019
Historique:
received:
12
07
2018
accepted:
24
06
2019
entrez:
28
7
2019
pubmed:
28
7
2019
medline:
31
12
2019
Statut:
epublish
Résumé
The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin of human liver parenchymal tissue generation during embryonic development, homeostasis or repair. Here we report the existence of a hepatobiliary hybrid progenitor (HHyP) population in human foetal liver using single-cell RNA sequencing. HHyPs are anatomically restricted to the ductal plate of foetal liver and maintain a transcriptional profile distinct from foetal hepatocytes, mature hepatocytes and mature BECs. In addition, molecular heterogeneity within the EpCAM
Identifiants
pubmed: 31350390
doi: 10.1038/s41467-019-11266-x
pii: 10.1038/s41467-019-11266-x
pmc: PMC6659636
doi:
Substances chimiques
Antigens, Neoplasm
0
Cell Adhesion Molecules
0
EPCAM protein, human
0
Epithelial Cell Adhesion Molecule
0
TACSTD2 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3350Subventions
Organisme : Medical Research Council
ID : MR/L006537/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S000011/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI099245
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109662
Pays : United States
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