Protective effects of Cotoneaster integerrimus on in vitro and ex-vivo models of H
Animals
Colon
/ drug effects
Dinoprostone
/ immunology
Fruit
/ chemistry
HCT116 Cells
Humans
Hydrogen Peroxide
/ toxicity
In Vitro Techniques
L-Lactate Dehydrogenase
/ genetics
Lipopolysaccharides
/ adverse effects
Male
Plant Extracts
/ pharmacology
Protective Agents
/ pharmacology
Rats
Rats, Sprague-Dawley
Rosaceae
/ chemistry
Tumor Necrosis Factor-alpha
/ genetics
Cotoneaster integerrimus
antioxidant
inflammation
natural agents
oxidative stress
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
17
11
2018
revised:
11
12
2018
accepted:
19
12
2018
entrez:
30
7
2019
pubmed:
30
7
2019
medline:
23
6
2020
Statut:
ppublish
Résumé
The present study evaluated the biological potential of methanol and aqueous extracts of the twigs and fruits of Cotoneaster integerrimus Medik. Lethality bioassays performed on Artemia salina showed that aqueous and methanol C. integerrimus extracts were non-toxic in the concentration range (0.1-20 mg/ml), with a LC50 ≥ 2.5 mg/ml, for each single extract. The protective effect of the extracts was assessed in vitro against hydrogen peroxide-induced lactate dehydrogenase (LDH) activity and tumor necrosis factor (TNF)α gene expression in colon cancer HCT116 cell line. All the extracts downregulated (H
Substances chimiques
Lipopolysaccharides
0
Plant Extracts
0
Protective Agents
0
Tumor Necrosis Factor-alpha
0
Hydrogen Peroxide
BBX060AN9V
L-Lactate Dehydrogenase
EC 1.1.1.27
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12766Informations de copyright
© 2019 Wiley Periodicals, Inc.