Raman Spectroscopy Follows Time-Dependent Changes in T Lymphocytes Isolated from Spleen of Endotoxemic Mice.

Animals CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / immunology Endotoxemia / pathology Inflammation / chemically induced Lipopolysaccharides / pharmacology Lymphocyte Activation / immunology Mice Mice, Inbred C57BL Placebos ROC Curve Spectrum Analysis, Raman / methods Spleen / pathology Time

Journal

ImmunoHorizons
ISSN: 2573-7732
Titre abrégé: Immunohorizons
Pays: United States
ID NLM: 101708159

Informations de publication

Date de publication:
08 02 2019
Historique:
received: 28 08 2018
accepted: 17 01 2019
entrez: 30 7 2019
pubmed: 30 7 2019
medline: 18 12 2019
Statut: epublish

Résumé

T lymphocytes (T cells) are highly specialized members of the adaptive immune system and hold the key to the understanding the hosts' response toward invading pathogen or pathogen-associated molecular patterns such as LPS. In this study, noninvasive Raman spectroscopy is presented as a label-free method to follow LPS-induced changes in splenic T cells during acute and postacute inflammatory phases (1, 4, 10, and 30 d) with a special focus on CD4

Identifiants

DOI: 10.4049/immunohorizons.1800059 PMID: 31356153
pubmed: 31356153
pii: 3/2/45
doi: 10.4049/immunohorizons.1800059
doi:

Substances chimiques

Lipopolysaccharides 0
Placebos 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

45-60

Informations de copyright

Copyright © 2019 The Authors.

Auteurs

Anuradha Ramoji (A)

Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany.
Leibniz Institute of Photonic Technology Jena, 07745 Jena, Germany.
Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, 07743 Jena, Germany.
ORCID: 0000-0003-2723-6614

Oleg Ryabchykov (O)

Leibniz Institute of Photonic Technology Jena, 07745 Jena, Germany.
Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, 07743 Jena, Germany.
ORCID: 0000-0002-4655-8080

Kerstin Galler (K)

Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany.
Leibniz Institute of Photonic Technology Jena, 07745 Jena, Germany.

Astrid Tannert (A)

Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany.
Leibniz Institute of Photonic Technology Jena, 07745 Jena, Germany.
Jena Biophotonics and Imaging Laboratory, 07745 Jena, Germany.

Robby Markwart (R)

Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany.

Robert P Requardt (RP)

Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany.

Ignacio Rubio (I)

Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany.
Department of Anesthesiology and Intensive Care, Jena University Hospital, 07747 Jena, Germany; and.

Michael Bauer (M)

Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany.
Jena Biophotonics and Imaging Laboratory, 07745 Jena, Germany.
Department of Anesthesiology and Intensive Care, Jena University Hospital, 07747 Jena, Germany; and.
ORCID: 0000-0002-1521-3514

Thomas Bocklitz (T)

Leibniz Institute of Photonic Technology Jena, 07745 Jena, Germany.
Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, 07743 Jena, Germany.
ORCID: 0000-0003-2778-6624

Jürgen Popp (J)

Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany.
Leibniz Institute of Photonic Technology Jena, 07745 Jena, Germany.
Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, 07743 Jena, Germany.
Jena Biophotonics and Imaging Laboratory, 07745 Jena, Germany.
InfectoGnostics Research Campus Jena, 07743 Jena, Germany.

Ute Neugebauer (U)

Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany; ute.neugebauer@med.uni-jena.de.
Leibniz Institute of Photonic Technology Jena, 07745 Jena, Germany.
Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, 07743 Jena, Germany.
Jena Biophotonics and Imaging Laboratory, 07745 Jena, Germany.
InfectoGnostics Research Campus Jena, 07743 Jena, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Bactériémie › Endotoxémie › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › Thérapeutique › Placebo › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Courbe ROC › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Analyse spectrale Raman › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Rate › Raman Spectroscopy Follows Time-Dependent...
questionsmedicales.fr › Phénomènes physiques › Temps › Raman Spectroscopy Follows Time-Dependent...