A Functional Virgin Olive Oil Enriched with Olive Oil and Thyme Phenolic Compounds Improves the Expression of Cholesterol Efflux-Related Genes: A Randomized, Crossover, Controlled Trial.
Biomarkers
/ blood
Cholesterol
/ blood
Cross-Over Studies
Double-Blind Method
Female
Food, Fortified
Gene Expression Regulation
Humans
Hypercholesterolemia
/ blood
Lipid Metabolism
/ genetics
Male
Middle Aged
Olive Oil
/ administration & dosage
Phenols
/ administration & dosage
Plant Extracts
/ administration & dosage
Thymus Plant
Time Factors
Treatment Outcome
HDL cholesterol
cholesterol efflux
functional virgin olive oil
olive oil phenolic compounds
thyme phenolic compounds
transcriptomics
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
26 Jul 2019
26 Jul 2019
Historique:
received:
11
07
2019
accepted:
25
07
2019
entrez:
31
7
2019
pubmed:
31
7
2019
medline:
21
1
2020
Statut:
epublish
Résumé
The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benefits are not fully understood. Our aim was to determine whether these functional VOOs could enhance the expression of cholesterol efflux-related genes. In a randomized, double-blind, crossover, controlled trial, 22 hypercholesterolemic subjects ingested for three weeks 25 mL/day of: (1) a functional VOO enriched with olive oil PCs (500 mg/kg); (2) a functional VOO enriched with olive oil (250 mg/kg) and thyme PCs (250 mg/kg; FVOOT), and; (3) a natural VOO (olive oil PCs: 80 mg/kg, control intervention). We assessed whether these interventions improved the expression of cholesterol efflux-related genes in peripheral blood mononuclear cells by quantitative reverse-transcription polymerase chain reactions. The FVOOT intervention upregulated the expression of
Identifiants
pubmed: 31357534
pii: nu11081732
doi: 10.3390/nu11081732
pmc: PMC6723782
pii:
doi:
Substances chimiques
Biomarkers
0
Olive Oil
0
Phenols
0
Plant Extracts
0
Cholesterol
97C5T2UQ7J
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : AGL2009-13517-C03-01
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : AGL2012-40144-C03-01
Organisme : Instituto de Salud Carlos III
ID : CB06/03/0028
Organisme : Instituto de Salud Carlos III
ID : CB07/08/0016
Organisme : Instituto de Salud Carlos III
ID : CD17/00122
Organisme : Instituto de Salud Carlos III
ID : CD17/00233
Organisme : Instituto de Salud Carlos III
ID : JR17/00022
Organisme : Agència de Gestió d'Ajuts Universitaris i de Recerca
ID : 2014-SGR-240
Organisme : Agència de Gestió d'Ajuts Universitaris i de Recerca
ID : 2017-SGR-522
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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