A Parasite Biomarker Set for Evaluating Benznidazole Treatment Efficacy in Patients with Chronic Asymptomatic Trypanosoma cruzi Infection.
Adult
Biomarkers
/ blood
CD8-Positive T-Lymphocytes
/ metabolism
Chagas Disease
/ drug therapy
Cytokines
/ metabolism
Enzyme-Linked Immunosorbent Assay
Female
Granzymes
/ metabolism
Humans
Male
Middle Aged
Nitroimidazoles
/ therapeutic use
Perforin
/ metabolism
Polymerase Chain Reaction
Trypanocidal Agents
/ therapeutic use
Trypanosoma cruzi
/ drug effects
Young Adult
Chagas disease
Trypanosoma cruzi
antibodies
benznidazole
biomarkers
cellular response
cytokines
cytotoxic molecules
seroconversion
therapeutic response
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
20
11
2018
accepted:
18
07
2019
pubmed:
31
7
2019
medline:
4
8
2020
entrez:
31
7
2019
Statut:
epublish
Résumé
One of the current greatest challenges of Chagas disease is the establishment of biomarkers to assess the efficacy of drugs in a short period of time. In this context, the reactivity of sera from 66 adults with chronic indeterminate Chagas disease (IND) for a set of four
Identifiants
pubmed: 31358581
pii: AAC.02436-18
doi: 10.1128/AAC.02436-18
pmc: PMC6761566
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Nitroimidazoles
0
Trypanocidal Agents
0
Perforin
126465-35-8
Granzymes
EC 3.4.21.-
benzonidazole
YC42NRJ1ZD
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
Références
Am J Trop Med Hyg. 2011 Apr;84(4):575-80
pubmed: 21460013
BMC Infect Dis. 2011 Jul 31;11:206
pubmed: 21801456
Int J Cardiol. 2015 Nov 15;199:451-9
pubmed: 26277551
PLoS Negl Trop Dis. 2016 Mar 14;10(3):e0004508
pubmed: 26974551
N Engl J Med. 2015 Nov 5;373(19):1882
pubmed: 26535522
Antimicrob Agents Chemother. 2014;58(2):635-9
pubmed: 24247135
JAMA. 2007 Nov 14;298(18):2171-81
pubmed: 18000201
J Cell Biol. 2006 Apr 10;173(1):133-44
pubmed: 16606695
PLoS Negl Trop Dis. 2018 Feb 9;12(2):e0006226
pubmed: 29425201
Clin Vaccine Immunol. 2012 Feb;19(2):167-73
pubmed: 22155766
PLoS Negl Trop Dis. 2018 Nov 1;12(11):e0006814
pubmed: 30383777
Mol Immunol. 1993 Aug;30(12):1115-21
pubmed: 8366861
Clin Vaccine Immunol. 2008 Feb;15(2):297-302
pubmed: 18057184
Rev Inst Med Trop Sao Paulo. 2013;55(3):
pubmed: 23740013
Acta Trop. 2010 Jul-Aug;115(1-2):22-7
pubmed: 19646412
J Infect Dis. 2004 Mar 1;189(5):909-18
pubmed: 14976609
Expert Rev Anti Infect Ther. 2013 Sep;11(9):957-76
pubmed: 24053276
Comput Struct Biotechnol J. 2016 Dec 14;15:98-103
pubmed: 28066534
Rev Soc Bras Med Trop. 2007 Jan-Feb;40(1):1-10
pubmed: 17486245
Acta Trop. 2016 Dec;164:117-124
pubmed: 27619190
Mem Inst Oswaldo Cruz. 2015 May;110(3):422-32
pubmed: 25946151
PLoS Pathog. 2009 Feb;5(2):e1000313
pubmed: 19247441
Front Immunol. 2016 Aug 11;7:306
pubmed: 27563302
Clin Infect Dis. 2013 Feb;56(4):496-502
pubmed: 23097582
J Am Coll Cardiol. 2010 Jun 1;55(22):2499-508
pubmed: 20510218
Mem Inst Oswaldo Cruz. 1999;94 Suppl 1:331-5
pubmed: 10677750
J Antimicrob Chemother. 2016 Jul;71(7):2005-9
pubmed: 27073267
Infect Dis Clin North Am. 2012 Jun;26(2):275-91
pubmed: 22632639
J Immunol. 2017 Apr 15;198(8):3170-3180
pubmed: 28258194
PLoS Negl Trop Dis. 2008 Oct 08;2(10):e316
pubmed: 18841200
Int J Cardiol. 2007 Feb 14;115(3):279-83
pubmed: 16769134
Int J Exp Pathol. 2010 Feb;91(1):72-86
pubmed: 19878357
Lancet. 2010 Apr 17;375(9723):1388-402
pubmed: 20399979
Acta Trop. 2010 Jul-Aug;115(1-2):14-21
pubmed: 19932071
Trans R Soc Trop Med Hyg. 2013 Jun;107(6):372-6
pubmed: 23612468
PLoS Negl Trop Dis. 2011 Sep;5(9):e1314
pubmed: 21909451
Int Immunol. 2006 Mar;18(3):465-71
pubmed: 16431876
Virology. 2015 May;479-480:180-93
pubmed: 25620767
Nat Med. 2008 May;14(5):542-50
pubmed: 18425131
Transfusion. 2013 Jun;53(6):1257-65
pubmed: 23002996
Am J Trop Med Hyg. 1993 Nov;49(5):625-35
pubmed: 8250103
J Immunol. 2015 Oct 15;195(8):3748-58
pubmed: 26385520
J Clin Microbiol. 2010 Apr;48(4):1139-49
pubmed: 20071547
Ann Intern Med. 2006 May 16;144(10):724-34
pubmed: 16702588
BMC Infect Dis. 2014 Jun 03;14:302
pubmed: 24894358
Expert Rev Anti Infect Ther. 2014 Apr;12(4):479-96
pubmed: 24621252