Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy.

Anaphase / drug effects Animals Apoptosis / drug effects Carcinogenesis / drug effects Cell Line, Tumor Cell Proliferation / drug effects Centrosome / drug effects Humans Lung Neoplasms / enzymology Mice Polyploidy Protein Kinase Inhibitors / pharmacology Protein-Tyrosine Kinases / antagonists & inhibitors Pyrazoles / pharmacology Pyrimidines / pharmacology

Journal

Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535

Informations de publication

Date de publication:
10 2019
Historique:
received: 02 08 2018
revised: 18 12 2018
accepted: 24 07 2019
pubmed: 31 7 2019
medline: 10 6 2020
entrez: 31 7 2019
Statut: ppublish

Résumé

The spindle assembly checkpoint maintains genomic integrity. A key component is tyrosine threonine kinase (TTK, also known as Mps1). TTK antagonism is hypothesized to cause genomic instability and cell death. Interrogating The Cancer Genome Atlas revealed high TTK expression in lung adenocarcinomas and squamous cell cancers versus the normal lung (

Identifiants

DOI: 10.1158/1535-7163.MCT-18-0864 PMID: 31358662
pubmed: 31358662
pii: 1535-7163.MCT-18-0864
doi: 10.1158/1535-7163.MCT-18-0864
doi:

Substances chimiques

CFI-402257 0
Protein Kinase Inhibitors 0
Pyrazoles 0
Pyrimidines 0
Protein-Tyrosine Kinases EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1775-1786

Informations de copyright

©2019 American Association for Cancer Research.

Auteurs

Lin Zheng (L)

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Zibo Chen (Z)

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Frederick National Laboratory for Cancer Research, Frederick, Maryland.

Masanori Kawakami (M)

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Frederick National Laboratory for Cancer Research, Frederick, Maryland.

Yulong Chen (Y)

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Jason Roszik (J)

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
ORCID: 0000-0002-4561-6170

Lisa Maria Mustachio (LM)

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Jonathan M Kurie (JM)

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Pamela Villalobos (P)

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Wei Lu (W)

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Carmen Behrens (C)

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Barbara Mino (B)

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Luisa M Solis (LM)

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
ORCID: 0000-0002-1253-630X

Jennifer Silvester (J)

The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Kelsie L Thu (KL)

The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

David W Cescon (DW)

The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Jaime Rodriguez-Canales (J)

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Ignacio I Wistuba (II)

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Tak W Mak (TW)

The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Xi Liu (X)

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Frederick National Laboratory for Cancer Research, Frederick, Maryland.

Ethan Dmitrovsky (E)

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. ethan.dmitrovsky@nih.gov.
Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Mitose › Anaphase › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Eucaryotes › Animaux › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Appareil du fuseau › Pôles du fuseau › Centrosome › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Phénomènes génétiques › Ploïdies › Polyploïdie › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrazoles › Tyrosine Threonine Kinase Inhibition...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Tyrosine Threonine Kinase Inhibition...