New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.

Adult Aged Alcohol Drinking / genetics Alcoholism / genetics Brain / physiopathology Female Genes / genetics Genetic Predisposition to Disease / genetics Genome-Wide Association Study Humans Magnetic Resonance Imaging Male Mental Disorders / genetics Middle Aged Neuroimaging Polymorphism, Single Nucleotide / genetics Quantitative Trait Loci / genetics Schizophrenia / genetics White People / genetics

Journal

Nature human behaviour
ISSN: 2397-3374
Titre abrégé: Nat Hum Behav
Pays: England
ID NLM: 101697750

Informations de publication

Date de publication:
09 2019
Historique:
received: 01 11 2018
accepted: 11 06 2019
pubmed: 31 7 2019
medline: 20 2 2020
entrez: 31 7 2019
Statut: ppublish

Résumé

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d

Identifiants

DOI: 10.1038/s41562-019-0653-z PMID: 31358974 PMC: PMC7711277
pubmed: 31358974
doi: 10.1038/s41562-019-0653-z
pii: 10.1038/s41562-019-0653-z
pmc: PMC7711277
mid: NIHMS1649425
doi:

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

950-961

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK093757
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0700704
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R023484/1
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA040439
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026818
Pays : United States
Organisme : Medical Research Council
ID : MR/R026505/1
Pays : United Kingdom
Organisme : NIAAA NIH HHS
ID : R01 AA019526
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : MRF
ID : MRF_MRF-058-0004-RG-DESRI
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL120393
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK072193
Pays : United States
Organisme : Medical Research Council
ID : MR/R00465X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L01341X/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH085772
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK062370
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : U01 DK062370
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K026992/1
Pays : United Kingdom

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Auteurs

Evangelos Evangelou (E)

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
ORCID: 0000-0002-5488-2999

He Gao (H)

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.

Congying Chu (C)

Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Georgios Ntritsos (G)

Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
ORCID: 0000-0002-6213-2901

Paul Blakeley (P)

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
NIHR Imperial Biomedical Research Centre, ITMAT Data Science Group, Imperial College London, London, UK.

Andrew R Butts (AR)

Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.

Raha Pazoki (R)

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.

Hideaki Suzuki (H)

Centre for Restorative Neurosciences, Division of Brain Sciences, Department of Medicine, Hammersmith Campus, Imperial College London, London, UK.
Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
ORCID: 0000-0002-0410-6940

Fotios Koskeridis (F)

Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
ORCID: 0000-0002-1253-7556

Andrianos M Yiorkas (AM)

Department of Life Sciences, Brunel University London, London, UK.
Section of Investigative Medicine, Imperial College London, London, UK.

Ibrahim Karaman (I)

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
UK Dementia Research Institute, Imperial College London, London, UK.
ORCID: 0000-0001-9341-8155

Joshua Elliott (J)

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.

Qiang Luo (Q)

Institute of Science and Technology for Brain-Inspired Intelligence, MOE-Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Department of Psychology and the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-0426-6039

Stefanie Aeschbacher (S)

Cardiology Division, University Hospital Basel, Basel, Switzerland.

Traci M Bartz (TM)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Biostatistics, University of Washington, Seattle, WA, USA.

Sebastian E Baumeister (SE)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Chair of Epidemiology, Ludwig-Maximilians-Universitat Munchen, UNIKA-T Augsburg, Augsburg, Germany.

Peter S Braund (PS)

Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Michael R Brown (MR)

Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Jennifer A Brody (JA)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
ORCID: 0000-0001-8509-148X

Toni-Kim Clarke (TK)

Department of Psychiatry, University of Edinburgh, Edinburgh, UK.

Niki Dimou (N)

Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
ORCID: 0000-0003-1678-9328

Jessica D Faul (JD)

Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.

Georg Homuth (G)

Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.

Anne U Jackson (AU)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-9672-2547

Katherine A Kentistou (KA)

Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-5816-664X

Peter K Joshi (PK)

Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-6361-5059

Rozenn N Lemaitre (RN)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.

Penelope A Lind (PA)

Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0002-3887-2598

Leo-Pekka Lyytikäinen (LP)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and LHealth Technology, Tampere University, Tampere, Finland.
Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
ORCID: 0000-0002-7200-5455

Massimo Mangino (M)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
NIHR Biomedical Research Centre, Guy's and St Thomas Foundation Trust, London, UK.
ORCID: 0000-0002-2167-7470

Yuri Milaneschi (Y)

Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands.

Christopher P Nelson (CP)

Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
ORCID: 0000-0001-8025-2897

Ilja M Nolte (IM)

Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
ORCID: 0000-0001-5047-4077

Mia-Maria Perälä (MM)

Folkhälsan Research Center, Helsinki, Finland.
Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
ORCID: 0000-0002-6349-6301

Ozren Polasek (O)

Faculty of Medicine, University of Split, Split, Croatia.

David Porteous (D)

Generation Scotland, Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK.
ORCID: 0000-0003-1249-6106

Scott M Ratliff (SM)

Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.

Jennifer A Smith (JA)

Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-3575-5468

Alena Stančáková (A)

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.

Alexander Teumer (A)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.
ORCID: 0000-0002-8309-094X

Samuli Tuominen (S)

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Sébastien Thériault (S)

Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec City, Quebec, Canada.

Jagadish Vangipurapu (J)

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.

John B Whitfield (JB)

Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0002-1103-0876

Alexis Wood (A)

Department of Pediatrics/Nutrition, Baylor College of Medicine, Houston, TX, USA.

Jie Yao (J)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

Bing Yu (B)

Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Wei Zhao (W)

Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0001-7388-0692

Dan E Arking (DE)

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Juha Auvinen (J)

Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Oulunkaari Health Center, Ii, Finland.

Chunyu Liu (C)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Minna Männikkö (M)

Northern Finland Birth Cohorts, Faculty of Medicine, University of Oulu, Oulu, Finland.

Lorenz Risch (L)

Institute of Clinical Chemistry, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.
Labormedizinisches Zentrum Dr. Risch, Vaduz, Liechtenstein.
Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.

Jerome I Rotter (JI)

The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0001-7191-1723

Harold Snieder (H)

Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Juha Veijola (J)

Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland.
Department of Psychiatry, University Hospital of Oulu, Oulu, Finland.
Medical research Center Oulu, University and University Hospital of Oulu, Oulu, Finland.

Alexandra I Blakemore (AI)

Department of Life Sciences, Brunel University London, London, UK.
Section of Investigative Medicine, Imperial College London, London, UK.

Michael Boehnke (M)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-6442-7754

Harry Campbell (H)

Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

David Conen (D)

Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

Johan G Eriksson (JG)

Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.
National Institute for Health and Welfare, Helsinki, Finland.
Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.

Hans J Grabe (HJ)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany.
ORCID: 0000-0003-3684-4208

Xiuqing Guo (X)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

Pim van der Harst (P)

Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands.
ORCID: 0000-0002-2713-686X

Catharina A Hartman (CA)

Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Caroline Hayward (C)

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
ORCID: 0000-0002-9405-9550

Andrew C Heath (AC)

Department of Psychiatry, School of Medicine, Washington University in St Louis, St Louis, MO, USA.

Marjo-Riitta Jarvelin (MR)

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Biocenter Oulu, University of Oulu, Oulu, Finland.
Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland.
Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.

Mika Kähönen (M)

Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Sharon L R Kardia (SLR)

Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.

Michael Kühne (M)

Cardiology Division, University Hospital Basel, Basel, Switzerland.

Johanna Kuusisto (J)

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.

Markku Laakso (M)

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
ORCID: 0000-0002-3394-7749

Jari Lahti (J)

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-4310-5297

Terho Lehtimäki (T)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and LHealth Technology, Tampere University, Tampere, Finland.

Andrew M McIntosh (AM)

Department of Psychiatry, University of Edinburgh, Edinburgh, UK.
Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK.
ORCID: 0000-0002-0198-4588

Karen L Mohlke (KL)

Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
ORCID: 0000-0001-6721-153X

Alanna C Morrison (AC)

Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Nicholas G Martin (NG)

Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0003-4069-8020

Albertine J Oldehinkel (AJ)

Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
ORCID: 0000-0003-3925-3913

Brenda W J H Penninx (BWJH)

Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands.

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Olli T Raitakari (OT)

Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.

Igor Rudan (I)

Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-6993-6884

Nilesh J Samani (NJ)

Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Laura J Scott (LJ)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-4886-5084

Tim D Spector (TD)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Niek Verweij (N)

Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
ORCID: 0000-0002-4303-7685

David R Weir (DR)

Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-1661-2402

James F Wilson (JF)

Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
ORCID: 0000-0001-5751-9178

Daniel Levy (D)

Framingham Heart Study, Framingham, MA, USA.
Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Ioanna Tzoulaki (I)

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
ORCID: 0000-0002-4275-9328

Jimmy D Bell (JD)

Research Centre for Optimal Health, Department of Life Sciences, University of Westminster, London, UK.
ORCID: 0000-0003-3804-1281

Paul M Matthews (PM)

Centre for Restorative Neurosciences, Division of Brain Sciences, Department of Medicine, Hammersmith Campus, Imperial College London, London, UK.
UK Dementia Research Institute, Imperial College London, London, UK.
ORCID: 0000-0002-1619-8328

Adrian Rothenfluh (A)

Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Departments of Psychiatry, Neurobiology & Anatomy, Human Genetics, School of Medicine, University of Utah, Salt Lake City, UT, USA.
ORCID: 0000-0002-3813-5723

Sylvane Desrivières (S)

Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
ORCID: 0000-0002-9120-7060

Gunter Schumann (G)

Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. gunter.schumann@kcl.ac.uk.
PONS Research Group, Dept of Psychiatry and Psychotherapy, Campus Charite Mitte, Humboldt University, Berlin, Germany and Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, P.R. China. gunter.schumann@kcl.ac.uk.
ORCID: 0000-0002-7740-6469

Paul Elliott (P)

Department of Epidemiology and Biostatistics, Imperial College London, London, UK. p.elliott@imperial.ac.uk.
MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. p.elliott@imperial.ac.uk.
UK Dementia Research Institute, Imperial College London, London, UK. p.elliott@imperial.ac.uk.
National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare NHS Trust and Imperial College London, London, UK. p.elliott@imperial.ac.uk.
Health Data Research UK London Substantive Site, London, UK. p.elliott@imperial.ac.uk.
ORCID: 0000-0002-7511-5684

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