The impact of antimicrobials on gonococcal evolution.
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
04
06
2018
accepted:
30
05
2019
pubmed:
31
7
2019
medline:
8
2
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
The sexually transmitted pathogen Neisseria gonorrhoeae is regarded as being on the way to becoming an untreatable superbug. Despite its clinical importance, little is known about its emergence and evolution, and how this corresponds with the introduction of antimicrobials. We present a genome-based phylogeographical analysis of 419 gonococcal isolates from across the globe. Results indicate that modern gonococci originated in Europe or Africa, possibly as late as the sixteenth century and subsequently disseminated globally. We provide evidence that the modern gonococcal population has been shaped by antimicrobial treatment of sexually transmitted infections as well as other infections, leading to the emergence of two major lineages with different evolutionary strategies. The well-described multidrug-resistant lineage is associated with high rates of homologous recombination and infection in high-risk sexual networks. A second, multisusceptible lineage is more associated with heterosexual networks, with potential implications for infection control.
Identifiants
pubmed: 31358980
doi: 10.1038/s41564-019-0501-y
pii: 10.1038/s41564-019-0501-y
pmc: PMC6817357
mid: EMS83238
doi:
Substances chimiques
Anti-Bacterial Agents
0
DNA, Bacterial
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1941-1950Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098051
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI132606
Pays : United States
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