Amyloid imaging of dutch-type hereditary cerebral amyloid angiopathy carriers.
Adult
Alzheimer Disease
/ genetics
Amyloid beta-Peptides
/ cerebrospinal fluid
Aniline Compounds
/ metabolism
Brain
/ blood supply
Case-Control Studies
Cerebral Amyloid Angiopathy, Familial
/ cerebrospinal fluid
Female
Functional Neuroimaging
Heterozygote
Humans
Male
Middle Aged
Neuroimaging
Positron-Emission Tomography
Thiazoles
/ metabolism
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
28
01
2019
revised:
24
07
2019
accepted:
24
07
2019
pubmed:
31
7
2019
medline:
21
4
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
To determine whether amyloid imaging with the positron emission tomography (PET) agent Pittsburgh compound B (PiB) can detect vascular β-amyloid (Aβ) in the essentially pure form of cerebral amyloid angiopathy associated with the Dutch-type hereditary cerebral amyloid angiopathy (D-CAA) mutation. PiB retention in a cortical composite of frontal, lateral, and retrosplenial regions (FLR) was measured by PiB-PET in 19 D-CAA mutation carriers (M D-CAA M Increased PiB retention in D-CAA and correlation with reduced CSF Aβ40 suggest this compound labels vascular amyloid, although to a lesser degree than amyloid deposits in ADAD. Progression in PiB signal over time suggests amyloid PET as a potential biomarker in trials of candidate agents for this untreatable cause of hemorrhagic stroke. ANN NEUROL 2019;86:616-625.
Identifiants
pubmed: 31361916
doi: 10.1002/ana.25560
pmc: PMC6876775
mid: NIHMS1059555
doi:
Substances chimiques
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
0
Amyloid beta-Peptides
0
Aniline Compounds
0
Thiazoles
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
616-625Subventions
Organisme : NINDS NIH HHS
ID : R01 NS070834
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG032438
Pays : United States
Organisme : NIA NIH HHS
ID : UF1 AG032438
Pays : United States
Informations de copyright
© 2019 American Neurological Association.
Références
Ann Neurol. 2007 Sep;62(3):229-34
pubmed: 17683091
Neurology. 2016 Aug 30;87(9):920-6
pubmed: 27473132
J Nucl Med. 2009 Mar;50(3):348-55
pubmed: 19223409
J Neurosci Res. 2007 Oct;85(13):2917-23
pubmed: 17628026
Neurology. 2015 Sep 1;85(9):790-8
pubmed: 26245925
J Nucl Med. 2014 Aug;55(8):1305-7
pubmed: 24898026
Ann Neurol. 2008 Nov;64(5):587-91
pubmed: 19067370
Neurology. 2017 Oct 3;89(14):1490-1498
pubmed: 28855406
JAMA Neurol. 2014 Nov;71(11):1379-85
pubmed: 25222039
Neurology. 2016 Nov 8;87(19):2043-2049
pubmed: 27605173
Neurology. 2017 Jan 10;88(2):169-176
pubmed: 27903811
Neurology. 2012 Jul 24;79(4):320-6
pubmed: 22786597
Sci Transl Med. 2014 Mar 5;6(226):226ra30
pubmed: 24598588
Stroke. 2009 Sep;40(9):3022-7
pubmed: 19556530
Ann Neurol. 2009 Aug;66(2):245-9
pubmed: 19743453
Neurology. 2010 Feb 9;74(6):487-93
pubmed: 20142615
Neuroimage. 2016 May 15;132:334-343
pubmed: 26915497
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
N Engl J Med. 2012 Aug 30;367(9):795-804
pubmed: 22784036
Neurology. 2014 May 20;82(20):1760-7
pubmed: 24748674
Stroke. 2016 Dec;47(12):3041-3044
pubmed: 27834748
Alzheimers Dement. 2017 Jan;13(1):8-19
pubmed: 27583651
Ann Neurol. 2016 Jan;79(1):110-9
pubmed: 26505746
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4502-9
pubmed: 24194552
J Biol Chem. 1996 Dec 13;271(50):32185-91
pubmed: 8943274
Brain Pathol. 2006 Jan;16(1):30-9
pubmed: 16612980
J Nucl Med. 1998 May;39(5):904-11
pubmed: 9591599
Curr Opin Neurol. 2018 Feb;31(1):28-35
pubmed: 29120920
Acta Neuropathol. 1994;88(4):371-8
pubmed: 7839831
Ann Neurol. 2010 Oct;68(4):545-8
pubmed: 20865701
Lancet Neurol. 2017 Feb;16(2):115-122
pubmed: 27989553
Ann Neurol. 2013 Apr;73(4):529-36
pubmed: 23424091
J Nucl Med. 2009 Dec;50(12):1975-9
pubmed: 19910429
ACS Chem Neurosci. 2017 Dec 20;8(12):2655-2666
pubmed: 28898051