Transposition favors the generation of large effect mutations that may facilitate rapid adaption.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
31 07 2019
31 07 2019
Historique:
received:
29
04
2019
accepted:
12
07
2019
entrez:
2
8
2019
pubmed:
2
8
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Transposable elements (TEs) are mobile parasitic sequences that have been repeatedly coopted during evolution to generate new functions and rewire gene regulatory networks. Yet, the contribution of active TEs to the creation of heritable mutations remains unknown. Using TE accumulation lines in Arabidopsis thaliana we show that once initiated, transposition produces an exponential spread of TE copies, which rapidly leads to high mutation rates. Most insertions occur near or within genes and targets differ between TE families. Furthermore, we uncover an essential role of the histone variant H2A.Z in the preferential integration of Ty1/copia retrotransposons within environmentally responsive genes and away from essential genes. We also show that epigenetic silencing of new Ty1/copia copies can affect their impact on major fitness-related traits, including flowering time. Our findings demonstrate that TEs are potent episodic (epi)mutagens that, thanks to marked chromatin tropisms, limit the mutation load and increase the potential for rapid adaptation.
Identifiants
pubmed: 31366887
doi: 10.1038/s41467-019-11385-5
pii: 10.1038/s41467-019-11385-5
pmc: PMC6668482
doi:
Substances chimiques
Arabidopsis Proteins
0
DNA Transposable Elements
0
H2A.Z protein, Arabidopsis
0
Histones
0
Retroelements
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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