Folate Receptor α-Targeted
Animals
Antibodies, Monoclonal, Humanized
/ chemistry
Antineoplastic Agents, Phytogenic
/ chemistry
Drug Therapy, Combination
Female
Folate Receptor 1
/ immunology
HeLa Cells
Humans
Immunoconjugates
/ chemistry
Male
Maytansine
/ analogs & derivatives
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, Nude
Mice, SCID
Molecular Targeted Therapy
/ methods
Paclitaxel
/ therapeutic use
Pemetrexed
/ therapeutic use
Positron Emission Tomography Computed Tomography
/ methods
Radioisotopes
/ chemistry
Tissue Distribution
Treatment Outcome
Triple Negative Breast Neoplasms
/ diagnostic imaging
Xenograft Model Antitumor Assays
Zirconium
/ chemistry
antibody−drug conjugate
companion diagnostic
folate receptor α
image-guided therapy
immuno-PET
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
03 09 2019
03 09 2019
Historique:
pubmed:
2
8
2019
medline:
9
6
2020
entrez:
2
8
2019
Statut:
ppublish
Résumé
Folate receptor α (FRα) is a well-studied tumor biomarker highly expressed in many epithelial tumors such as breast, ovarian, and lung cancers. Mirvetuximab soravtansine (IMGN853) is the antibody-drug conjugate of FRα-binding humanized monoclonal antibody M9346A and cytotoxic maytansinoid drug DM4. IMGN853 is currently being evaluated in multiple clinical trials, in which the immunohistochemical evaluation of an archival tumor or biopsy specimen is used for patient screening. However, limited tissue collection may lead to inaccurate diagnosis due to tumor heterogeneity. Herein, we developed a zirconium-89 (
Identifiants
pubmed: 31369274
doi: 10.1021/acs.molpharmaceut.9b00653
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Antineoplastic Agents, Phytogenic
0
FOLR1 protein, human
0
Folate Receptor 1
0
Immunoconjugates
0
Radioisotopes
0
Pemetrexed
04Q9AIZ7NO
Maytansine
14083FR882
mirvetuximab soravtansine
98DE7VN88D
Zirconium
C6V6S92N3C
Zirconium-89
NTM296JU95
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3996-4006Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM103422
Pays : United States