The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane.
3T3-L1 Cells
Adenosine Triphosphatases
/ metabolism
Amino Acid Sequence
Animals
Cell Line, Tumor
Cell Membrane
/ metabolism
Cell Polarity
/ physiology
Cytoplasm
/ metabolism
Endocytosis
Enzyme Activation
HCT116 Cells
Hep G2 Cells
Human Umbilical Vein Endothelial Cells
Humans
MCF-7 Cells
Membrane Transport Proteins
/ metabolism
Mice
Protein Isoforms
Protein Kinase C
/ metabolism
RAW 264.7 Cells
Cell polarity
Flippase
Membrane lipids
P-type ATPase
P4-ATPase
Transporters
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
02 09 2019
02 09 2019
Historique:
received:
10
03
2019
accepted:
22
07
2019
pubmed:
3
8
2019
medline:
15
8
2020
entrez:
3
8
2019
Statut:
epublish
Résumé
ATP11C, a member of the P4-ATPase family, is a major phosphatidylserine (PS)-flippase located at the plasma membrane. ATP11C deficiency causes a defect in B-cell maturation, anemia and hyperbilirubinemia. Although there are several alternatively spliced variants derived from the
Identifiants
pubmed: 31371488
pii: jcs.231720
doi: 10.1242/jcs.231720
pii:
doi:
Substances chimiques
Membrane Transport Proteins
0
Protein Isoforms
0
Protein Kinase C
EC 2.7.11.13
ATP11C protein, human
EC 3.6.1.-
ATP11C protein, mouse
EC 3.6.1.-
Adenosine Triphosphatases
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.