Genetic Characterization and Prognostic Relevance of Acquired Uniparental Disomies in Cytogenetically Normal Acute Myeloid Leukemia.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
received:
01
03
2019
revised:
06
06
2019
accepted:
30
07
2019
pubmed:
4
8
2019
medline:
9
9
2020
entrez:
4
8
2019
Statut:
ppublish
Résumé
Uniparental disomy (UPD) is a way cancer cells duplicate a mutated gene, causing loss of heterozygosity (LOH). Patients with cytogenetically normal acute myeloid leukemia (CN-AML) do not have microscopically detectable chromosome abnormalities, but can harbor UPDs. We examined the prognostic significance of UPDs and frequency of LOH in patients with CN-AML. We detected 127 UPDs in 109 patients. Most UPDs were large and typically encompassed all or most of the affected chromosome arm. The most common UPDs occurred on chromosome arms 13q (7.5% of patients), 6p (2.8%), and 11p (2.8%). Many UPDs significantly cooccurred with mutations in genes they encompassed, including 13q UPD with LOH mediated by UPD is a recurrent feature of CN-AML. Detection of UPDs of 13q and 11p might be useful for genetic risk stratification of patients with CN-AML.
Identifiants
pubmed: 31375516
pii: 1078-0432.CCR-19-0725
doi: 10.1158/1078-0432.CCR-19-0725
pmc: PMC6825549
mid: NIHMS1536703
doi:
Substances chimiques
Nuclear Proteins
0
Banques de données
ClinicalTrials.gov
['NCT00085124', 'NCT00742625', 'NCT00651261', 'NCT00006363', 'NCT00900224', 'NCT00048958', 'NCT00899223', 'NCT00003190']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6524-6531Subventions
Organisme : NCI NIH HHS
ID : U10 CA077658
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016056
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180821
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180850
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA233180
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA233191
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180833
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180867
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197734
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180861
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA233331
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180882
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA233338
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA196171
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016058
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180866
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA233339
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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