The Secret Life of Chromosome Loops upon DNA Double-Strand Break.
DNA double-strand breaks repair
DSB clustering
chromatin
topologically associating domains
γH2AX
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
07 02 2020
07 02 2020
Historique:
received:
23
05
2019
revised:
24
07
2019
accepted:
30
07
2019
pubmed:
12
8
2019
medline:
8
8
2020
entrez:
12
8
2019
Statut:
ppublish
Résumé
DNA double-strand breaks (DSBs) are harmful lesions that severely challenge genomic integrity, and recent evidence suggests that DSBs occur more frequently on the genome than previously thought. These lesions activate a complex and multilayered response called the DNA damage response, which allows to coordinate their repair with the cell cycle progression. While the mechanistic details of repair processes have been narrowed, thanks to several decades of intense studies, our knowledge of the impact of DSB on chromatin composition and chromosome architecture is still very sparse. However, the recent development of various tools to induce DSB at annotated loci, compatible with next-generation sequencing-based approaches, is opening a new framework to tackle these questions. Here we discuss the influence of initial and DSB-induced chromatin conformation and the strong potential of 3C-based technologies to decipher the contribution of chromosome architecture during DSB repair.
Identifiants
pubmed: 31401119
pii: S0022-2836(19)30497-8
doi: 10.1016/j.jmb.2019.07.036
pmc: PMC7057266
pii:
doi:
Substances chimiques
Chromatin
0
Macromolecular Substances
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
724-736Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no competing interest to declare.
Références
Radiat Prot Dosimetry. 2006;122(1-4):150-3
pubmed: 17229782
J Cell Sci. 2017 Mar 15;130(6):1134-1146
pubmed: 28167679
Cell Rep. 2019 May 7;27(6):1809-1821.e5
pubmed: 31067465
EMBO J. 2010 Apr 21;29(8):1446-57
pubmed: 20360682
Genes Dev. 2012 Jul 1;26(13):1473-85
pubmed: 22751501
Nat Commun. 2018 Jul 2;9(1):2567
pubmed: 29967403
PLoS Genet. 2019 Mar 1;15(3):e1008001
pubmed: 30822309
Mol Cell Oncol. 2016 Mar 10;3(3):e1134411
pubmed: 27314089
Genes Dev. 2014 Nov 15;28(22):2450-63
pubmed: 25366693
Cell. 2015 Nov 5;163(4):880-93
pubmed: 26544937
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9169-74
pubmed: 24927542
Curr Biol. 2012 Sep 11;22(17):1564-75
pubmed: 22771042
Mol Cell. 2016 Sep 1;63(5):898-911
pubmed: 27477910
Curr Biol. 2011 Sep 13;21(17):1421-30
pubmed: 21856158
Trends Cell Biol. 2019 Jun;29(6):462-476
pubmed: 30954333
Nature. 2011 Sep 11;477(7365):424-30
pubmed: 21909113
Sci Rep. 2017 Mar 06;7:43530
pubmed: 28262757
Science. 2009 Oct 9;326(5950):289-93
pubmed: 19815776
Nat Methods. 2013 Apr;10(4):361-5
pubmed: 23503052
Curr Opin Cell Biol. 2017 Jun;46:81-86
pubmed: 28431265
EMBO J. 2019 Aug 15;38(16):e101379
pubmed: 31267591
PLoS Genet. 2012 Jan;8(1):e1002460
pubmed: 22275873
Nat Immunol. 2004 May;5(5):481-7
pubmed: 15077110
J Mol Biol. 2017 May 5;429(9):1277-1288
pubmed: 28363678
Cell. 2011 Aug 5;146(3):372-83
pubmed: 21816273
Curr Genet. 2019 Feb;65(1):1-9
pubmed: 29947969
Mol Cell. 2011 May 6;42(3):319-29
pubmed: 21549309
Mol Cell. 2019 Jul 25;75(2):267-283.e12
pubmed: 31202576
Cell. 2018 May 17;173(5):1165-1178.e20
pubmed: 29706548
Mol Cell. 2004 Dec 22;16(6):1003-15
pubmed: 15610742
Mol Cell. 2018 Oct 18;72(2):250-262.e6
pubmed: 30270107
Nature. 2017 Jul 13;547(7662):241-245
pubmed: 28636597
Chromosoma. 2018 Sep;127(3):291-300
pubmed: 29594515
Nat Commun. 2015 Aug 19;6:8088
pubmed: 26286827
Cell. 2015 Jun 18;161(7):1592-605
pubmed: 26052046
Nat Commun. 2019 Oct 22;10(1):4795
pubmed: 31641121
Genes Dev. 2009 Apr 15;23(8):912-27
pubmed: 19390086
Front Oncol. 2016 Jun 28;6:163
pubmed: 27446809
EMBO J. 2017 Sep 1;36(17):2609-2625
pubmed: 28754657
Nature. 2018 Jul;559(7712):54-60
pubmed: 29925946
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10912-10917
pubmed: 28973861
Nucleic Acids Res. 2015 Sep 18;43(16):7931-44
pubmed: 26206670
Mol Cell. 2016 Feb 18;61(4):547-562
pubmed: 26895424
Cell. 2017 Jul 27;170(3):507-521.e18
pubmed: 28735753
J Cell Sci. 2012 May 1;125(Pt 9):2127-33
pubmed: 22328517
Cell. 2002 Dec 13;111(6):791-802
pubmed: 12526806
Science. 2008 Oct 24;322(5901):597-602
pubmed: 18948542
Semin Cancer Biol. 2016 Jun;37-38:51-64
pubmed: 27016036
Genes Dev. 2015 Jun 1;29(11):1151-63
pubmed: 26019174
Nat Struct Mol Biol. 2017 Apr;24(4):353-361
pubmed: 28263325
Nature. 2017 Jul 13;547(7662):236-240
pubmed: 28636604
Mol Cell. 2019 Jul 25;75(2):252-266.e8
pubmed: 31202577
Mol Biol Cell. 2017 Jun 15;28(12):1701-1711
pubmed: 28450453
Nucleic Acids Res. 2010 Jan;38(2):477-87
pubmed: 19906707
Mol Biol Cell. 2016 Dec 1;27(24):3791-3799
pubmed: 27733626
Trends Genet. 2019 May;35(5):330-345
pubmed: 30898334
Nat Struct Mol Biol. 2019 Mar;26(3):164-174
pubmed: 30778236
Nucleic Acids Res. 2009 Oct;37(18):6054-63
pubmed: 19700769
Science. 2013 Feb 8;339(6120):711-5
pubmed: 23306439
DNA Repair (Amst). 2019 Sep;81:102661
pubmed: 31331819
Mol Cell. 2019 Jan 17;73(2):212-223.e7
pubmed: 30554942
J Cell Biol. 2006 Mar 13;172(6):823-34
pubmed: 16520385
J Cell Biol. 2009 May 18;185(4):577-86
pubmed: 19451271
Cell. 2010 Dec 10;143(6):924-37
pubmed: 21145459
J Cell Biol. 2011 Apr 4;193(1):81-95
pubmed: 21464229
Nucleus. 2015;6(2):107-13
pubmed: 25675367
Cell. 2018 Jun 28;174(1):102-116.e14
pubmed: 29804837
Cell. 2012 Mar 2;148(5):908-21
pubmed: 22341456
Cell Rep. 2016 Jun 28;16(1):48-55
pubmed: 27320916
Cell Rep. 2014 Dec 11;9(5):1703-1717
pubmed: 25464843
Mol Cell. 2019 Jan 3;73(1):48-60.e5
pubmed: 30449725
EMBO J. 2006 Jul 26;25(14):3377-88
pubmed: 16810316
Science. 2007 Jul 13;317(5835):245-8
pubmed: 17626885
Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E146-54
pubmed: 26715752
Dev Cell. 2015 Mar 23;32(6):663-4
pubmed: 25805132
Cell. 2015 Aug 13;162(4):708-11
pubmed: 26276627
DNA Repair (Amst). 2017 Aug;56:102-108
pubmed: 28663070
Nat Cell Biol. 2006 Aug;8(8):870-6
pubmed: 16862143
Elife. 2015 Aug 19;4:e07735
pubmed: 26287480
Nucleic Acids Res. 2013 Jun;41(11):5784-98
pubmed: 23589625
Mol Cell. 2009 May 15;34(3):311-21
pubmed: 19450529
Adv Exp Med Biol. 2018;1044:27-38
pubmed: 29956289
EMBO J. 2018 Nov 15;37(22):
pubmed: 30305303
Mol Cell. 2019 Feb 7;73(3):547-561.e6
pubmed: 30735655
PLoS Biol. 2010 Oct 19;8(10):e1000519
pubmed: 20976046
Cell Cycle. 2016;15(1):13-21
pubmed: 26730703
Curr Opin Cell Biol. 2017 Jun;46:1-8
pubmed: 28068556
Mol Cell. 2018 Oct 18;72(2):222-238.e11
pubmed: 30293786
Nature. 2018 Jul;559(7712):61-66
pubmed: 29925947
Nat Commun. 2017 Jun 12;8:15760
pubmed: 28604675
J Immunol. 2017 Mar 15;198(6):2434-2444
pubmed: 28159901
DNA Repair (Amst). 2014 Jul;19:163-8
pubmed: 24754998
Cell Rep. 2017 Jan 31;18(5):1200-1214
pubmed: 28147275
Mol Cell. 2016 Jan 21;61(2):260-73
pubmed: 26725008
Mol Cell. 2016 Jul 21;63(2):293-305
pubmed: 27397684
Curr Biol. 2001 Jun 26;11(12):991-5
pubmed: 11448778
PLoS Genet. 2010 Jul 01;6(7):e1001006
pubmed: 20617204
Nature. 2015 Apr 2;520(7545):114-8
pubmed: 25539084
Biochem Biophys Res Commun. 2011 Aug 12;411(4):762-7
pubmed: 21784059
Sci Adv. 2017 May 24;3(5):e1601898
pubmed: 28560323
Nat Struct Mol Biol. 2019 Mar;26(3):175-184
pubmed: 30778237
Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):443-8
pubmed: 22184222
PLoS Genet. 2019 Apr 18;15(4):e1008103
pubmed: 30998688
Nat Struct Mol Biol. 2014 Jan;21(1):103-9
pubmed: 24336221
Nucleus. 2017 Nov 2;8(6):589-599
pubmed: 29099269
Cell Rep. 2015 Oct 13;13(2):251-9
pubmed: 26440899
Genes Dev. 2002 Mar 1;16(5):571-82
pubmed: 11877377
Genes Dev. 2002 Mar 1;16(5):560-70
pubmed: 11877376
Nat Struct Mol Biol. 2012 Aug;19(8):803-10
pubmed: 22773103
Mol Cell. 2013 Mar 7;49(5):858-71
pubmed: 23333305
Science. 2007 Jul 13;317(5835):242-5
pubmed: 17626884
Nat Methods. 2016 Oct;13(10):855-7
pubmed: 27525976
EMBO J. 2017 Sep 1;36(17):2595-2608
pubmed: 28694242
Cell Rep. 2014 Jun 26;7(6):2006-18
pubmed: 24931610
Nat Commun. 2017 May 12;8:15058
pubmed: 28497783
Nat Struct Mol Biol. 2011 Jun 05;18(7):831-9
pubmed: 21642969
Science. 2004 Jan 2;303(5654):92-5
pubmed: 14704429
Cancer Res. 2015 Apr 1;75(7):1311-21
pubmed: 25634209
Nucleus. 2016 Jul 3;7(4):339-45
pubmed: 27326661
PLoS Genet. 2010 Jan 15;6(1):e1000817
pubmed: 20090939
Mol Cell. 2004 Dec 22;16(6):991-1002
pubmed: 15610741
Science. 2002 Feb 15;295(5558):1306-11
pubmed: 11847345
Mol Syst Biol. 2018 Jul 16;14(7):e8293
pubmed: 30012718
Science. 2013 Feb 8;339(6120):700-4
pubmed: 23306437
Commun Biol. 2018 Oct 31;1:181
pubmed: 30393778
Nat Struct Mol Biol. 2014 Apr;21(4):366-74
pubmed: 24658350
Mol Cell. 2013 Jan 10;49(1):43-54
pubmed: 23246437
DNA Repair (Amst). 2017 Aug;56:84-91
pubmed: 28624372
Nat Cell Biol. 2013 Jun;15(6):694-9
pubmed: 23644470
J Biol Chem. 1998 Mar 6;273(10):5858-68
pubmed: 9488723
Cell Cycle. 2009 Nov 15;8(22):3750-69
pubmed: 19855159
Nat Cell Biol. 2015 Nov;17(11):1401-11
pubmed: 26502056
Mol Cell Biol. 2014 Feb;34(4):685-98
pubmed: 24324008
Oncotarget. 2018 Feb 7;9(17):13612-13622
pubmed: 29568381
Cell. 2014 Sep 25;159(1):108-121
pubmed: 25259924
Nat Rev Mol Cell Biol. 2019 Nov;20(11):698-714
pubmed: 31263220
Cell Rep. 2015 Nov 24;13(8):1598-609
pubmed: 26586426