Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.

Alleles Autoimmune Diseases / genetics Female Genetic Predisposition to Disease HLA Antigens / genetics Humans Lymphoma, Non-Hodgkin / genetics Male Middle Aged Multifactorial Inheritance / genetics Polymorphism, Single Nucleotide / genetics Risk Factors
autoimmune disease genome-wide association study meta-analysis non-Hodgkin lymphoma

Journal

Genetic epidemiology
ISSN: 1098-2272
Titre abrégé: Genet Epidemiol
Pays: United States
ID NLM: 8411723

Informations de publication

Date de publication:
10 2019
Historique:
received: 21 01 2019
revised: 01 05 2019
accepted: 07 05 2019
pubmed: 14 8 2019
medline: 23 11 2019
entrez: 14 8 2019
Statut: ppublish

Résumé

Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.

Identifiants

DOI: 10.1002/gepi.22242 PMID: 31407831 PMC: PMC6763347
pubmed: 31407831
doi: 10.1002/gepi.22242
pmc: PMC6763347
mid: NIHMS1032416
doi:

Substances chimiques

HLA Antigens 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

844-863

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Informations de copyright

© 2019 Wiley Periodicals, Inc.

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Auteurs

Lennox Din (L)

College of Medicine, California Northstate University, Elk Grove, California.

Mohammad Sheikh (M)

College of Medicine, California Northstate University, Elk Grove, California.

Nikitha Kosaraju (N)

Center for Neuroengineering and Therapeutics, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Karin Ekstrom Smedby (KE)

Division of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Solna, Sweden.

Sasha Bernatsky (S)

Faculty of Medicine, McGill University, Montreal, Canada.
Clinical Epidemiology, McGill University Health Centre, Research Institute, Montreal, Canada.

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Christine F Skibola (CF)

School of Medicine, Emory University, Atlanta, Georgia.

Alexandra Nieters (A)

Centre of Chronic Immunodeficiency, University Medical Centre Freiburg, Freiburg im Breisgau, Germany.

Sophia Wang (S)

Department of Population Sciences, City of Hope and the Beckman Research Institute, Duarte, California.

James D McKay (JD)

International Agency for Research on Cancer, Lyon, France.

Pierluigi Cocco (P)

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Sardinia, Italy.

Marc Maynadié (M)

The University of Burgundy-Franche-Comté and CHU Dijon Bourgogne, Registre des Hémopathies Malignes de Côte d'Or, INSERM U1231, Dijon, France.

Lenka Foretová (L)

Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Anthony Staines (A)

School of Nursing and Human Science, Dublin City University, Dublin, Ireland.

Thomas M Mack (TM)

Norris Comprehensive Cancer Center and Hospital, University of Southern California, Los Angeles, California.

Silvia de Sanjosé (S)

Reproductive Health Global Program PATH, School of Public Health, University of Washington, Seattle, Washington, USA.
Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Institut Català d' Oncologia, (IDIBELL), Barcelona, Spain.
Centro de Investigación Biomédica en Red, Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

Timothy J Vyse (TJ)

Department of Medical and Molecular Genetics, King's College London, London, England.

Leonid Padyukov (L)

Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Alain Monnereau (A)

Center of Research in Epidemiology and Statistics, Sorbonne (CRESS), Epidemiology of Childhood and Adolescent Cancer Group, INSERM, Paris, France.
Registre des Hémopathies Malignes de la Gironde, Institut Bergonie, Bordeaux, France.

Alan A Arslan (AA)

Department of Obstetrics and Gynecology, Department of Population Health, Department of Environmental Medicine, NYU School of Medicine, New York, New York.

Amy Moore (A)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Angela R Brooks-Wilson (AR)

Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada.
Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.

Anne J Novak (AJ)

Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

Bengt Glimelius (B)

Department of Immunology, Genetics, and Pathology, Uppsala Universitet, Uppsala, Sweden.

Brenda M Birmann (BM)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Brian K Link (BK)

Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Carolyn Stewart (C)

Memorial Sloan Kettering Cancer Center, New York, New York.

Claire M Vajdic (CM)

Centre for Big Data Research in Health, University of New South Wales, Kensington, Australia.

Corinne Haioun (C)

Lymphoid Malignancies Unit, Henri Mondor Hospital, University Paris-Est Créteil (UPEC), Paris, France.

Corrado Magnani (C)

Medicina Traslazionale, Università del Piemonte Orientale, Vercelli, Italy.

David V Conti (DV)

Department of Preventive Medicine, University of Southern California, Los Angeles, Califonia.

David G Cox (DG)

Centre de Recherche en Cancerologie de Lyon, Lyon, France.

Delphine Casabonne (D)

Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Institut Català d' Oncologia, (IDIBELL), Barcelona, Spain.
Centro de Investigación Biomédica en Red, Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

Demetrius Albanes (D)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Eleanor Kane (E)

Department of Health Sciences, University of York, York, England.

Eve Roman (E)

Department of Health Sciences, University of York, York, England.

Giacomo Muzi (G)

Department of Medicine, Universita degli Studi di Perugia, Perugia, Italy.

Gilles Salles (G)

Hematology Department, Centre Hospitalier Universitaire de Lyon, Lyon, France.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Australia.

Hans-Olov Adami (HO)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Clinical Effectiveness Research Group, Institute of Health, University of Oslo, Oslo, Norway.

Hervé Ghesquières (H)

Hematology Department, Centre Hospitalier Universitaire de Lyon, Lyon, France.

Immaculata De Vivo (I)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Jacqueline Clavel (J)

Department of Environmental Epidemiology of Cancers, INSERM, Paris, France.

James R Cerhan (JR)

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
ORCID: 0000-0002-7482-178X

John J Spinelli (JJ)

Population Oncology, British Columbia Cancer Agency, Vancouver, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.

Jonathan Hofmann (J)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Joseph Vijai (J)

Memorial Sloan Kettering Cancer Center, New York, New York.

Karen Curtin (K)

Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake, Utah.

Karen H Costenbader (KH)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Kenan Onel (K)

Department of Pediatrics, University of Chicago, Chicago, Illinois.

Kenneth Offit (K)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.

Lauren R Teras (LR)

Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.

Lindsay Morton (L)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Lucia Conde (L)

Bill Lyons Informatics Centre, UCL Cancer Institute, University College London Cancer Institute, London, England.

Lucia Miligi (L)

Environmental and Occupational Epidemiology Branch, Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research Prevention and Clinical Network (ISPRO), Florence, Florence, Italy.

Mads Melbye (M)

Department of Epidemiology Research, Statens Serum Institut, København, Denmark.
School of Medicine, Stanford University, Stanford, California.

Maria Grazia Ennas (MG)

School of Biomedical Sciences, University of Calgary, Calgary, Canada.

Mark Liebow (M)

Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

Mark P Purdue (MP)

Division of Cancer Biology, National Cancer Institute, Bethesda, Maryland.

Martha Glenn (M)

Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake, Utah.

Melissa C Southey (MC)

Department of Clinical Pathology, Genetic Epidemiology Laboratory, University of Melbourne, Melbourne, Australia.
Precision Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia.

Morris Din (M)

California State University, Sacramento, Califonia.

Nathaniel Rothman (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Nicola J Camp (NJ)

Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake, Utah.
Department of Biomedical Informatics, University of Utah, Salt Lake, Utah.

Nicole Wong Doo (N)

Clinical School, Concord Hospital, University of Sydney, Sydney, Australia.
Centre for Epidemiology and Intelligence, Cancer Council Australia, Melbourne, Australia.

Nikolaus Becker (N)

Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

Nisha Pradhan (N)

Memorial Sloan Kettering Cancer Center, New York, New York.

Paige M Bracci (PM)

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.

Paolo Boffetta (P)

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Paolo Vineis (P)

School of Public Health, Imperial College London, London, England.

Paul Brennan (P)

International Agency for Research on Cancer, Lyon, France.

Peter Kraft (P)

Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, Massachusetts.

Qing Lan (Q)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Richard K Severson (RK)

Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan.

Roel C H Vermeulen (RCH)

Division of Environmental Epidemiology, Institute for Risk Assessment Science, Utrecht University, Utrecht, Netherlands.

Roger L Milne (RL)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Australia.
Centre for Epidemiology and Intelligence, Cancer Council Australia, Melbourne, Australia.

Rudolph Kaaks (R)

Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.

Ruth C Travis (RC)

Cancer Epidemiology Unit, University of Oxford, Oxford, England.

Stephanie J Weinstein (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Stephen M Ansell (SM)

Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

Susan L Slager (SL)

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.

Tongzhang Zheng (T)

School of Public Health, Brown University, Providence, Rhode Island.

Yawei Zhang (Y)

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut.

Yolanda Benavente (Y)

Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Institut Català d' Oncologia, (IDIBELL), Barcelona, Spain.
Centro de Investigación Biomédica en Red, Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

Zachary Taub (Z)

University of California, Davis, California.

Lohith Madireddy (L)

Department of Neurology, University of California, San Francisco, California.

Pierre-Antoine Gourraud (PA)

Centre de Recherche en Transplantation et Immunologie, Université de Nantes, Centre Hospitalier Universitaire (CHU, INSERM), Nantes, France.
Santé Publique, Clinique des Données, Centre Hospitalier Universitaire (CHU) de Nantes, INSERM, Nantes, France.

Jorge R Oksenberg (JR)

Department of Neurology, University of California, San Francisco, California.

Wendy Cozen (W)

Departments of Preventive Medicine and Pathology, Norris Comprehensive Cancer Center and Hospital, University of Southern California, Los Angeles, California.

Henrik Hjalgrim (H)

Department of Epidemiology Research, Statens Serum Institut, København, Denmark.

Pouya Khankhanian (P)

Center for Neuroengineering and Therapeutics, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
ORCID: 0000-0001-8075-4176

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Genetic overlap between autoimmune diseases...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Genetic overlap between autoimmune diseases...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genetic overlap between autoimmune diseases...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Genetic overlap between autoimmune diseases...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic overlap between autoimmune diseases...
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