Protective Effects of a Neurohypophyseal Hormone Analogue on Prion Aggregation, Cellular Internalization, and Toxicity.

Hormones Humans Prion Diseases Prion Proteins Prions Protein Conformation, beta-Strand
Prion amyloid desmopressin microscopy oligomer toxicity

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
19 08 2020
Historique:
pubmed: 14 8 2019
medline: 22 6 2021
entrez: 14 8 2019
Statut: ppublish

Résumé

Herein, we report novel neuroprotective activity of the neurohypophyseal hormone analogue desmopressin (DDAVP) against toxic conformations of human prion protein. Systematic analysis using biophysical techniques in conjunction with surface plasmon resonance, high-end microscopy, conformational antibodies, and cell-based assays demonstrated DDAVP's specific binding and potent antiaggregating effects on prion protein (

Identifiants

DOI: 10.1021/acschemneuro.9b00299 PMID: 31407881
pubmed: 31407881
doi: 10.1021/acschemneuro.9b00299
doi:

Substances chimiques

Hormones 0
Prion Proteins 0
Prions 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2422-2430

Auteurs

Nikita Admane (N)

School of Biotechnology, Jawaharlal Nehru University, New Delhi, India - 110067.

Ankit Srivastava (A)

Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India - 110016.

Salma Jamal (S)

School of Biotechnology, Jawaharlal Nehru University, New Delhi, India - 110067.

Bishwajit Kundu (B)

Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India - 110016.

Abhinav Grover (A)

School of Biotechnology, Jawaharlal Nehru University, New Delhi, India - 110067.
ORCID: 0000-0002-3296-7860

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Protective Effects of a Neurohypophyseal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Protective Effects of a Neurohypophyseal...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladies à prions › Protective Effects of a Neurohypophyseal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Prions › Protéines prion › Protective Effects of a Neurohypophyseal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Prions › Protective Effects of a Neurohypophyseal...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Structure en brin bêta › Protective Effects of a Neurohypophyseal...