Extinction training following cocaine or MDMA self-administration produces discrete changes in D
Animals
Behavior, Animal
/ drug effects
Brain
/ drug effects
Cocaine
/ administration & dosage
Drug-Seeking Behavior
/ drug effects
Extinction, Psychological
Male
N-Methyl-3,4-methylenedioxyamphetamine
/ administration & dosage
Rats, Wistar
Receptor, Metabotropic Glutamate 5
/ metabolism
Receptors, Dopamine D2
/ metabolism
Reinforcement Schedule
Self Administration
Cocaine self-administration
Dopamine D(2)-like receptor
Extinction training
Glutamate mGlu(5) receptor
MDMA self-administration
Reinstatement of seeking-behavior
Journal
Pharmacological reports : PR
ISSN: 2299-5684
Titre abrégé: Pharmacol Rep
Pays: Switzerland
ID NLM: 101234999
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
04
02
2019
revised:
11
04
2019
accepted:
06
05
2019
pubmed:
14
8
2019
medline:
1
5
2020
entrez:
14
8
2019
Statut:
ppublish
Résumé
Several studies strongly support the role of the dopamine D The present study employed cocaine or MDMA self-administration with yoked-triad procedure in rats to explore whether extinction training affects the drug-seeking behavior and the D Both cocaine and MDMA rats developed maintenance of self-administration, but MDMA evoked lower response rates and speed of self-administration acquisition. During reinstatement tests, cocaine or MDMA seeking behavior was produced by either exposure to the drug-associated cues or drug-priming injections. The extinction training after cocaine self-administration did not alter significantly D This study first time shows that abstinence followed extinction training after cocaine or MDMA self- or passive-injections changes the D
Sections du résumé
BACKGROUND
BACKGROUND
Several studies strongly support the role of the dopamine D
METHODS
METHODS
The present study employed cocaine or MDMA self-administration with yoked-triad procedure in rats to explore whether extinction training affects the drug-seeking behavior and the D
RESULTS
RESULTS
Both cocaine and MDMA rats developed maintenance of self-administration, but MDMA evoked lower response rates and speed of self-administration acquisition. During reinstatement tests, cocaine or MDMA seeking behavior was produced by either exposure to the drug-associated cues or drug-priming injections. The extinction training after cocaine self-administration did not alter significantly D
CONCLUSION
CONCLUSIONS
This study first time shows that abstinence followed extinction training after cocaine or MDMA self- or passive-injections changes the D
Identifiants
pubmed: 31408786
pii: S1734-1140(19)30080-5
doi: 10.1016/j.pharep.2019.05.001
pii:
doi:
Substances chimiques
Grm5 protein, rat
0
Receptor, Metabotropic Glutamate 5
0
Receptors, Dopamine D2
0
Cocaine
I5Y540LHVR
N-Methyl-3,4-methylenedioxyamphetamine
KE1SEN21RM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
870-878Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2019 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.