Pharmacological exposures may precipitate craniosynostosis through targeted stem cell depletion.
Animals
Citalopram
/ pharmacology
Craniosynostoses
/ etiology
Culture Media
/ chemistry
Down-Regulation
/ drug effects
Female
Male
Mice
Mice, Inbred C57BL
Nicotine
/ pharmacology
Selective Serotonin Reuptake Inhibitors
/ pharmacology
Skull
/ anatomy & histology
Stem Cells
/ drug effects
Thyroid Hormones
/ pharmacology
Thyroxine
/ pharmacology
Zinc Finger Protein GLI1
/ genetics
Craniosynostosis
Gli1
Stem cells
Teratogens
Journal
Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
19
04
2019
revised:
29
07
2019
accepted:
05
08
2019
pubmed:
16
8
2019
medline:
1
5
2020
entrez:
16
8
2019
Statut:
ppublish
Résumé
The Centers for Disease Control and Prevention, National Birth Defects Study suggests that environmental exposures including maternal thyroid diseases, maternal nicotine use, and use of selective serotonin reuptake inhibitors (SSRIs) may exacerbate incidence and or severity of craniofacial abnormalities including craniosynostosis. Premature fusion of a suture(s) of the skull defines the birth defect craniosynostosis which occurs in 1:1800-2500 births. A proposed mechanism of craniosynostosis is the disruption of proliferation and differentiation of cells in the perisutural area. Here, we hypothesize that pharmacological exposures including excess thyroid hormone, nicotine, and SSRIs lead to an alteration of stem cells within the sutures resulting in premature fusion. In utero exposure to nicotine and citalopram (SSRI) increased the risk of premature suture fusion in a wild-type murine model. Gli1
Identifiants
pubmed: 31415959
pii: S1873-5061(19)30158-8
doi: 10.1016/j.scr.2019.101528
pmc: PMC6915957
mid: NIHMS1544434
pii:
doi:
Substances chimiques
Culture Media
0
Serotonin Uptake Inhibitors
0
Thyroid Hormones
0
Zinc Finger Protein GLI1
0
Citalopram
0DHU5B8D6V
Nicotine
6M3C89ZY6R
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101528Subventions
Organisme : NIDCR NIH HHS
ID : T32 DE017551
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM103331
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000062
Pays : United States
Organisme : BLRD VA
ID : I01 BX000333
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG036675
Pays : United States
Organisme : NIDCR NIH HHS
ID : R03 DE023350
Pays : United States
Organisme : NIDCR NIH HHS
ID : F31 DE026684
Pays : United States
Organisme : NIDCR NIH HHS
ID : R03 DE026192
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
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