Cardiopulmonary effects of dexmedetomidine, with and without vatinoxan, in isoflurane-anesthetized cats.
Adrenergic alpha-2 Receptor Antagonists
/ administration & dosage
Anesthetics, Inhalation
/ administration & dosage
Animals
Blood Pressure
/ drug effects
Cats
Cross-Over Studies
Dexmedetomidine
/ administration & dosage
Dose-Response Relationship, Drug
Drug Interactions
Heart Rate
/ drug effects
Hypnotics and Sedatives
/ administration & dosage
Hypotension
/ chemically induced
Isoflurane
/ administration & dosage
Male
Quinolizines
/ administration & dosage
Vascular Resistance
/ drug effects
cardiovascular
cats
α(2)-agonist
α(2)-antagonist
Journal
Veterinary anaesthesia and analgesia
ISSN: 1467-2995
Titre abrégé: Vet Anaesth Analg
Pays: United States
ID NLM: 100956422
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
04
02
2019
revised:
27
05
2019
accepted:
30
05
2019
pubmed:
17
8
2019
medline:
13
3
2020
entrez:
17
8
2019
Statut:
ppublish
Résumé
To characterize the cardiopulmonary effects of dexmedetomidine, with or without vatinoxan, in isoflurane-anesthetized cats. Randomized, crossover experimental study. A group of six adult healthy male neutered cats. Cats were instrumented during anesthesia with isoflurane in oxygen. Isoflurane end-tidal concentration was set to 1.25 minimum alveolar concentration (MAC). Dexmedetomidine was administered using a target-controlled infusion system to achieve and maintain 10 target plasma concentrations ranging from 0 to 40 ng mL Dexmedetomidine alone resulted in decreased HR, cardiac index, stroke index and oxygen delivery, and increased systolic, mean (MAP) and diastolic arterial pressure, CVP, PAP, PAOP, systemic vascular resistance index, rate-pressure product, left ventricular stroke work index and oxygen extraction ratio. Vatinoxan resulted in severe hypotension at target plasma dexmedetomidine concentrations <10 ng mL Vatinoxan, at the plasma concentration maintained in this study, attenuated the cardiovascular effects of dexmedetomidine in isoflurane-anesthetized cats. However, its administration resulted in hypotension, which may limit its clinical usefulness.
Identifiants
pubmed: 31416697
pii: S1467-2987(19)30162-X
doi: 10.1016/j.vaa.2019.05.012
pii:
doi:
Substances chimiques
Adrenergic alpha-2 Receptor Antagonists
0
Anesthetics, Inhalation
0
Hypnotics and Sedatives
0
Quinolizines
0
vatinoxan
342EYN0QFD
Dexmedetomidine
67VB76HONO
Isoflurane
CYS9AKD70P
Types de publication
Journal Article
Randomized Controlled Trial, Veterinary
Langues
eng
Sous-ensembles de citation
IM
Pagination
753-764Informations de copyright
Copyright © 2019 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.