α-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury.
Animals
Biomarkers
/ metabolism
Cardiotonic Agents
/ metabolism
Cytokines
/ metabolism
Flow Cytometry
Gene Expression Profiling
Inflammation
/ drug therapy
Inflammation Mediators
/ metabolism
Lipid Metabolism
/ drug effects
Lipid Peroxidation
/ drug effects
Male
Mice
Myocardial Reperfusion Injury
/ drug therapy
Oxidation-Reduction
/ drug effects
Oxidative Stress
/ drug effects
Reactive Oxygen Species
/ metabolism
Transcriptome
alpha-Tocopherol
/ metabolism
Ischemia/reperfusion injury
Myocardial infarction
Oxidative stress
ROS-Sensitive nanoprobe
Tocopherol
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
10
07
2019
accepted:
05
08
2019
pubmed:
17
8
2019
medline:
28
2
2020
entrez:
17
8
2019
Statut:
ppublish
Résumé
Myocardial infarction (MI) is a leading cause of mortality and morbidity worldwide and new treatment strategies are highly sought-after. Paradoxically, reperfusion of the ischemic myocardium, as achieved with early percutaneous intervention, results in substantial damage to the heart (ischemia/reperfusion injury) caused by cell death due to aggravated inflammatory and oxidative stress responses. Chronic therapy with vitamin E is not effective in reducing the cardiovascular event rate, presumably through failing to reduce atherosclerotic plaque instability. Notably, acute treatment with vitamin E in patients suffering a MI has not been systematically investigated. We applied alpha-tocopherol (α-TOH), the strongest anti-oxidant form of vitamin E, in murine cardiac ischemia/reperfusion injury induced by ligation of the left anterior descending coronary artery for 60 min. α-TOH significantly reduced infarct size, restored cardiac function as measured by ejection fraction, fractional shortening, cardiac output, and stroke volume, and prevented pathological changes as assessed by state-of-the-art strain and strain-rate analysis. Cardioprotective mechanisms identified, include a decreased infiltration of neutrophils into cardiac tissue and a systemic anti-inflammatory shift from Ly6C Overall, α-TOH inhibits ischemia/reperfusion injury-induced oxidative and inflammatory responses, and ultimately preserves cardiac function. Therefore, our study provides a strong incentive to test vitamin E as an acute therapy in patients suffering a MI.
Identifiants
pubmed: 31419755
pii: S2213-2317(19)30800-6
doi: 10.1016/j.redox.2019.101292
pmc: PMC6831864
pii:
doi:
Substances chimiques
Biomarkers
0
Cardiotonic Agents
0
Cytokines
0
Inflammation Mediators
0
Reactive Oxygen Species
0
alpha-Tocopherol
H4N855PNZ1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101292Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
Références
Am J Clin Nutr. 1995 Dec;62(6 Suppl):1527S-1534S
pubmed: 7495255
Arch Physiol Biochem. 1999 Feb;107(1):27-34
pubmed: 10455556
FASEB J. 2000 Jan;14(1):87-94
pubmed: 10627283
Cardiovasc Res. 2019 Jan 1;115(1):179-189
pubmed: 29850765
Biochem Biophys Res Commun. 2000 Nov 2;277(3):531-4
pubmed: 11061988
Biochem Biophys Res Commun. 2008 May 9;369(3):868-72
pubmed: 18328805
J Immunol Res. 2015;2015:817038
pubmed: 26579547
Cardiovasc Drugs Ther. 1991 Mar;5 Suppl 2:309-12
pubmed: 1854670
J Nutr Biochem. 2008 May;19(5):320-7
pubmed: 17683924
Circulation. 1989 Nov;80(5 Pt 2):III14-8
pubmed: 2805294
Biochem Biophys Res Commun. 2004 Jul 2;319(3):1047-52
pubmed: 15184087
Br J Anaesth. 2003 Feb;90(2):148-54
pubmed: 12538369
J Gerontol A Biol Sci Med Sci. 2017 Sep 01;72(9):1277-1283
pubmed: 26975982
Circulation. 1983 May;67(5):1016-23
pubmed: 6831665
J Am Coll Cardiol. 2007 May 22;49(20):1993-2000
pubmed: 17512353
Annu Rev Physiol. 1995;57:311-32
pubmed: 7778871
Free Radic Biol Med. 2010 Nov 1;49(8):1315-22
pubmed: 20692332
J Lipid Res. 2000 Oct;41(10):1543-51
pubmed: 11013295
Nature. 2014 Nov 20;515(7527):431-435
pubmed: 25383517
Eur J Pharmacol. 2002 Dec 5;456(1-3):29-37
pubmed: 12450566
Circ Res. 1987 Nov;61(5):757-60
pubmed: 2822281
Food Chem. 2012 Sep 15;134(2):920-5
pubmed: 23107708
Jundishapur J Nat Pharm Prod. 2014 Apr 06;9(2):e17187
pubmed: 24872945
J Nutr Biochem. 2009 Jan;20(1):45-61
pubmed: 18495460
Int J Vitam Nutr Res. 2000 Dec;70(6):293-300
pubmed: 11214354
EFSA J. 2022 Jan 24;20(1):e200102
pubmed: 35106096
Environ Toxicol Pharmacol. 2013 Mar;35(2):207-17
pubmed: 23328120
Biochim Biophys Acta. 1989 Oct 17;1005(3):225-32
pubmed: 2804051
Thromb Haemost. 2013 Sep;110(3):501-14
pubmed: 23740239
Nutr Res. 2008 Oct;28(10):671-80
pubmed: 19083475
Ann N Y Acad Sci. 1988;524:103-21
pubmed: 2837948
Indian J Physiol Pharmacol. 1997 Jul;41(3):241-7
pubmed: 10232768
J Lipid Res. 2013 Oct;54(10):2898-908
pubmed: 23868910
J Lipid Res. 2001 Apr;42(4):521-7
pubmed: 11290823
J Immunol. 2015 Feb 1;194(3):1090-9
pubmed: 25512603
Fed Regist. 2016 May 27;81(103):33741-999
pubmed: 27236870
Med Sci (Basel). 2018 Apr 18;6(2):
pubmed: 29669993
Indian J Physiol Pharmacol. 2007 Apr-Jun;51(2):165-9
pubmed: 18175661
Circulation. 2010 Jun 8;121(22):2437-45
pubmed: 20530020
Food Chem Toxicol. 1986 Oct-Nov;24(10-11):1051-61
pubmed: 3542757
Expert Opin Ther Targets. 2009 Aug;13(8):945-56
pubmed: 19534573
Cardiovasc Res. 2002 Jan;53(1):31-47
pubmed: 11744011
J Thorac Cardiovasc Surg. 1994 Aug;108(2):302-10
pubmed: 8041178
Circulation. 2019 Mar 5;139(10):e56-e528
pubmed: 30700139
Adv Myocardiol. 1982;3:621-7
pubmed: 7170447
Exp Physiol. 2011 Jul;96(7):635-46
pubmed: 21527542
Ann Thorac Surg. 1989 Apr;47(4):553-7
pubmed: 2712629
Mol Nutr Food Res. 2014 Aug;58(8):1610-9
pubmed: 25044667
Eur Heart J. 2017 Apr 1;38(13):935-941
pubmed: 27118196
FEBS J. 2013 Jun;280(12):2806-16
pubmed: 23506295
Front Cell Infect Microbiol. 2017 May 03;7:161
pubmed: 28516066
Am J Cardiol. 1989 Nov 1;64(16):971-4
pubmed: 2816755
S Afr Med J. 1987 May 2;71(9):561-3
pubmed: 3576402
Free Radic Biol Med. 1991;10(5):315-24
pubmed: 1855672
Circ Res. 2019 Jun 21;125(1):29-40
pubmed: 31219752
Ann N Y Acad Sci. 1972 Dec 18;203:223-36
pubmed: 4633111
Trials. 2014 May 29;15:192
pubmed: 24885600
Sci Rep. 2016 Dec 02;6:38161
pubmed: 27909290
Biochim Biophys Acta. 2016 Oct;1861(10):1513-24
pubmed: 26924249
Arch Biochem Biophys. 2004 Mar 1;423(1):97-102
pubmed: 14871472
Free Radic Biol Med. 2013 Dec;65:1291-1299
pubmed: 24075893
Crit Care. 2018 Mar 20;22(1):70
pubmed: 29558975
J Lipid Res. 2013 Sep;54(9):2307-14
pubmed: 23505320
Redox Biol. 2014 Feb 19;2:495-503
pubmed: 24624339
J Nutr. 2002 Oct;132(10):3113-8
pubmed: 12368403
Physiol Res. 2001;50(4):389-96
pubmed: 11551145
Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1102-11
pubmed: 15790935
Eur Heart J. 2018 Jan 7;39(2):111-116
pubmed: 28472483
J Biol Chem. 2002 Jul 12;277(28):25290-6
pubmed: 11997390
Saudi Med J. 2010 Feb;31(2):142-7
pubmed: 20174728
Curr Top Med Chem. 2013;13(2):115-38
pubmed: 23470074