Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer.


Journal

Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042

Informations de publication

Date de publication:
11 2019
Historique:
received: 23 07 2019
revised: 08 08 2019
accepted: 14 08 2019
pubmed: 20 8 2019
medline: 29 7 2020
entrez: 18 8 2019
Statut: ppublish

Résumé

Despite effective strategies, resistance in HER2

Identifiants

pubmed: 31420371
pii: 1541-7786.MCR-19-0756
doi: 10.1158/1541-7786.MCR-19-0756
pmc: PMC6825570
mid: NIHMS1537921
doi:

Substances chimiques

Antineoplastic Agents 0
Lapatinib 0VUA21238F
ERBB2 protein, human EC 2.7.10.1
Receptor, ErbB-2 EC 2.7.10.1
Mechanistic Target of Rapamycin Complex 1 EC 2.7.11.1
Trastuzumab P188ANX8CK
Mevalonic Acid S5UOB36OCZ

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2318-2330

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA058183
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA186784
Pays : United States

Informations de copyright

©2019 American Association for Cancer Research.

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Auteurs

Vidyalakshmi Sethunath (V)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas.

Huizhong Hu (H)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Carmine De Angelis (C)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Jamunarani Veeraraghavan (J)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Lanfang Qin (L)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Nicholas Wang (N)

Department of Biomedical Engineering and OHSU Center for Spatial Systems Biomedicine, Portland, Oregon.

Lukas M Simon (LM)

Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.

Tao Wang (T)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.

Xiaoyong Fu (X)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Agostina Nardone (A)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Resel Pereira (R)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Sarmistha Nanda (S)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Obi L Griffith (OL)

McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri.

Anna Tsimelzon (A)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Chad Shaw (C)

Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas.

Gary C Chamness (GC)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Department of Medicine, Baylor College of Medicine, Houston, Texas.

Jorge S Reis-Filho (JS)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Britta Weigelt (B)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Laura M Heiser (LM)

Department of Biomedical Engineering and OHSU Center for Spatial Systems Biomedicine, Portland, Oregon.

Susan G Hilsenbeck (SG)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Shixia Huang (S)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.

Mothaffar F Rimawi (MF)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Department of Medicine, Baylor College of Medicine, Houston, Texas.

Joe W Gray (JW)

Department of Biomedical Engineering and OHSU Center for Spatial Systems Biomedicine, Portland, Oregon.

C Kent Osborne (CK)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Department of Medicine, Baylor College of Medicine, Houston, Texas.

Rachel Schiff (R)

Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas. rschiff@bcm.edu.
Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Department of Medicine, Baylor College of Medicine, Houston, Texas.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.

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Classifications MeSH