First case report of bacteremia caused by Solobacterium moorei in China, and literature review.
Anti-Bacterial Agents
/ therapeutic use
Bacteremia
/ drug therapy
China
Gram-Positive Bacteria
/ drug effects
Gram-Positive Bacterial Infections
/ drug therapy
Halitosis
/ etiology
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Purpura, Thrombotic Thrombocytopenic
/ complications
RNA, Ribosomal, 16S
/ genetics
Blood stream infection
China
Solobacterium moorei
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
20 Aug 2019
20 Aug 2019
Historique:
received:
25
01
2019
accepted:
06
08
2019
entrez:
21
8
2019
pubmed:
21
8
2019
medline:
27
11
2019
Statut:
epublish
Résumé
Solobacterium moorei, the only species in the genus Solobacterium, is a Gram-positive, non-spore-forming, strict anaerobic, short to long bacillus. It has rarely been documented to cause blood stream infections. Here we report the first case of bacteremia caused by S.moorei in China. A 61-year-old male presented to Peking Union Medical College Hospital (Beijing) with thrombotic thrombocytopenic purpura (TTP) and several other underlying diseases. He also had persistent coma accompanied by intermittent convulsions, halitosis, and intermittent fever. Blood cultures taken when the patient had a high fever were positive, with the anaerobic bottle yielding an organism identified as S.moorei by 16S rRNA gene sequencing, whilst the aerobic bottle grew Streptococcus mitis. After replacement of venous pipeline, and empirical use of vancomycin and meropenem, the patient's body temperature and white blood cell count returned to normal. Unfortunately, the patient died of severe TTP. This is the first case report of S. moorei isolation from blood stream in China. 16S rRNA gene sequencing is the only method that can identify S. moorei. Blood cultures must be taken before administration of antibiotics, and anaerobic culture should be considered for such rare pathogens in patients with oral diseases and immune deficiency.
Sections du résumé
BACKGROUND
BACKGROUND
Solobacterium moorei, the only species in the genus Solobacterium, is a Gram-positive, non-spore-forming, strict anaerobic, short to long bacillus. It has rarely been documented to cause blood stream infections. Here we report the first case of bacteremia caused by S.moorei in China.
CASE PRESENTATION
METHODS
A 61-year-old male presented to Peking Union Medical College Hospital (Beijing) with thrombotic thrombocytopenic purpura (TTP) and several other underlying diseases. He also had persistent coma accompanied by intermittent convulsions, halitosis, and intermittent fever. Blood cultures taken when the patient had a high fever were positive, with the anaerobic bottle yielding an organism identified as S.moorei by 16S rRNA gene sequencing, whilst the aerobic bottle grew Streptococcus mitis. After replacement of venous pipeline, and empirical use of vancomycin and meropenem, the patient's body temperature and white blood cell count returned to normal. Unfortunately, the patient died of severe TTP.
CONCLUSION
CONCLUSIONS
This is the first case report of S. moorei isolation from blood stream in China. 16S rRNA gene sequencing is the only method that can identify S. moorei. Blood cultures must be taken before administration of antibiotics, and anaerobic culture should be considered for such rare pathogens in patients with oral diseases and immune deficiency.
Identifiants
pubmed: 31429713
doi: 10.1186/s12879-019-4359-7
pii: 10.1186/s12879-019-4359-7
pmc: PMC6700775
doi:
Substances chimiques
Anti-Bacterial Agents
0
RNA, Ribosomal, 16S
0
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
730Subventions
Organisme : CAMS Innovation Fund for Medical Sciences (CIFMS)
ID : 2016-I2M-1-014
Organisme : The National Major Science and Technology Project for the Control and Prevention of Major Infectious Diseases of China
ID : 2017ZX10103004
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