CD33 splice site genotype was not associated with outcomes of patients receiving the anti-CD33 drug conjugate SGN-CD33A.
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal, Humanized
/ administration & dosage
Antineoplastic Agents, Immunological
/ administration & dosage
Female
Genotype
Humans
Immunoconjugates
/ administration & dosage
Leukemia, Myeloid, Acute
/ drug therapy
Male
Middle Aged
Polymorphism, Single Nucleotide
RNA Splicing
Sialic Acid Binding Ig-like Lectin 3
/ genetics
Survival Rate
Treatment Outcome
Acute myeloid leukemia
Antibody-drug conjugate
CD33
Journal
Journal of hematology & oncology
ISSN: 1756-8722
Titre abrégé: J Hematol Oncol
Pays: England
ID NLM: 101468937
Informations de publication
Date de publication:
22 08 2019
22 08 2019
Historique:
received:
07
05
2019
accepted:
12
08
2019
entrez:
24
8
2019
pubmed:
24
8
2019
medline:
1
8
2020
Statut:
epublish
Résumé
We tested whether a single nucleotide polymorphism (SNP) that affects splicing of CD33 predicted response to treatment in adults with acute myeloid leukemia (AML) who received the novel CD33 antibody-drug conjugate SGN-CD33A. This genotype, for the CD33 splice site SNP rs12459419, was not associated with clinical response (30% CR/CRi in both groups), event-free survival, or overall survival.
Identifiants
pubmed: 31439003
doi: 10.1186/s13045-019-0771-0
pii: 10.1186/s13045-019-0771-0
pmc: PMC6704571
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Antineoplastic Agents, Immunological
0
CD33 protein, human
0
Immunoconjugates
0
Sialic Acid Binding Ig-like Lectin 3
0
lintuzumab
V00Y10W60W
Types de publication
Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
85Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA230319
Pays : United States
Références
Blood. 2007 May 15;109(10):4168-70
pubmed: 17227830
Lancet Oncol. 2014 Aug;15(9):986-96
pubmed: 25008258
Ann Hematol. 2015 Mar;94(3):361-73
pubmed: 25284166
Expert Rev Hematol. 2016;9(4):335-50
pubmed: 26778118
J Clin Oncol. 2016 Mar 1;34(7):747-55
pubmed: 26786921
Blood. 2016 Apr 28;127(17):2157-60
pubmed: 26929274
Leukemia. 2017 May;31(5):1059-1068
pubmed: 27795558
J Clin Oncol. 2017 Aug 10;35(23):2674-2682
pubmed: 28644774
Blood. 2018 Jan 25;131(4):468-471
pubmed: 29229596
Expert Opin Investig Drugs. 2018 Apr;27(4):339-348
pubmed: 29534618