Connectivity of the human insula: A cortico-cortical evoked potential (CCEP) study.
Brain networks
Connectivity
Cortico-cortical evoked potentials
Epilepsy
Insula
Stereo-EEG
Journal
Cortex; a journal devoted to the study of the nervous system and behavior
ISSN: 1973-8102
Titre abrégé: Cortex
Pays: Italy
ID NLM: 0100725
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
13
03
2019
revised:
02
05
2019
accepted:
22
05
2019
pubmed:
24
8
2019
medline:
31
10
2020
entrez:
24
8
2019
Statut:
ppublish
Résumé
The human insula is increasingly being implicated as a multimodal functional network hub involved in a large variety of complex functions. Due to its inconspicuous location and highly vascular anatomy, it has historically been difficult to study. Cortico-cortical evoked potentials (CCEPs), utilize low frequency stimulation to map cerebral networks. They were used to study connections of the human insula. CCEP data was acquired from each sub-region of the dominant and non-dominant insula in 30 patients who underwent stereo-EEG. Connectivity strength to the various cortical regions was obtained via a measure of root mean square (RMS), calculated from each gyrus of the insula and ranked into weighted means. The results of all cumulative CCEP responses for each individual gyrus were represented by circro plots. Forty-nine individual CCEP pairs were stimulated across all the gyri from the right and left insula. In brief, the left insula contributed more greatly to language areas. Sensory function, pain, saliency processing and vestibular function were more heavily implicated from the right insula. Connections to the primary auditory cortex arose from both insula regions. Both posterior insula regions showed significant contralateral connectivity. Ipsilateral mesial temporal connections were seen from both insula regions. In visual function, we further report the novel finding of a direct connection between the right posterior insula and left visual cortex. The insula is a major multi-modal network hub with the cerebral cortex having major roles in language, sensation, auditory, visual, limbic and vestibular functions as well as saliency processing. In temporal lobe epilepsy surgery failure, the insula may be implicated as an extra temporal cause, due to the strong mesial temporal connectivity findings.
Identifiants
pubmed: 31442863
pii: S0010-9452(19)30230-8
doi: 10.1016/j.cortex.2019.05.019
pmc: PMC6825888
mid: NIHMS1532095
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
419-442Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB026299
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS089212
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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