The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells.
Antineoplastic Agents
/ pharmacology
Apoptosis
/ drug effects
Calcium
/ metabolism
Caspase 3
/ metabolism
Caspase 7
/ metabolism
Cell Line, Tumor
Cisplatin
/ pharmacology
Drug Resistance, Neoplasm
/ drug effects
Drug Screening Assays, Antitumor
G1 Phase Cell Cycle Checkpoints
/ drug effects
Humans
Membrane Potential, Mitochondrial
/ drug effects
Xanthones
/ pharmacology
Apoptosis
Caspase activation
Cisplatin resistance
Configurational free energy computations
Mitochondrial membrane potential
Phomoxanthone A
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
received:
09
05
2019
revised:
18
07
2019
accepted:
06
08
2019
pubmed:
25
8
2019
medline:
21
10
2020
entrez:
25
8
2019
Statut:
ppublish
Résumé
Platinum compounds are the first-line therapy for many types of cancer. However, drug resistance has frequently been reported for and is a major limitation of platinum-based chemotherapy in the clinic. In the current study, we examined the anti-tumor activity of phomoxanthone A (PXA), a tetrahydroxanthone dimer isolated from the endophytic fungus Phomopsis longicolla, in several solid cancer cell lines and their cisplatin-resistant sub-cell lines. PXA showed strong cytotoxic effects with IC
Identifiants
pubmed: 31443950
pii: S0968-0896(19)30785-0
doi: 10.1016/j.bmc.2019.115044
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Xanthones
0
phomoxanthone A
0
CASP3 protein, human
EC 3.4.22.-
CASP7 protein, human
EC 3.4.22.-
Caspase 3
EC 3.4.22.-
Caspase 7
EC 3.4.22.-
Cisplatin
Q20Q21Q62J
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115044Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.