Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage.

Adolescent Adult B-Lymphocytes / immunology Cell Differentiation / immunology Child Child, Preschool Common Variable Immunodeficiency / immunology Endotoxemia / immunology Female Humans IgA Deficiency / immunology Male Middle Aged T-Lymphocytes, Regulatory / immunology
Common variable immunodeficiency activin A autoimmune cytopenias endotoxin follicular helper T cell recent thymic emigrant regulatory T cell time-of-flight cytometry

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
12 2019
Historique:
received: 12 04 2019
revised: 26 07 2019
accepted: 05 08 2019
pubmed: 25 8 2019
medline: 9 6 2020
entrez: 25 8 2019
Statut: ppublish

Résumé

Although chiefly a B-lymphocyte disorder, several research groups have identified common variable immunodeficiency (CVID) subjects with numeric and/or functional T We sought to determine how circulating CD4 Using hypothesis-generating, high-dimensional single-cell analyses, we created comprehensive phenotypic maps of circulating CD4 Although CD4 Endotoxemia is associated with early commitment to the follicular T-cell lineage in IgA-deficient CVID subjects, particularly those with AICs.

Sections du résumé

BACKGROUND
Although chiefly a B-lymphocyte disorder, several research groups have identified common variable immunodeficiency (CVID) subjects with numeric and/or functional T
OBJECTIVE
We sought to determine how circulating CD4
METHODS
Using hypothesis-generating, high-dimensional single-cell analyses, we created comprehensive phenotypic maps of circulating CD4
RESULTS
Although CD4
CONCLUSIONS
Endotoxemia is associated with early commitment to the follicular T-cell lineage in IgA-deficient CVID subjects, particularly those with AICs.

Identifiants

DOI: 10.1016/j.jaci.2019.08.007 PMID: 31445098 PMC: PMC6900457
pubmed: 31445098
pii: S0091-6749(19)31092-9
doi: 10.1016/j.jaci.2019.08.007
pmc: PMC6900457
mid: NIHMS1538097
pii:
doi:

Types de publication

Clinical Trial Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1660-1673

Subventions

Organisme : NCI NIH HHS
ID : P01 CA210944
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI117950
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI146026
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD043245
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI108545
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105343
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI115001
Pays : United States

Informations de copyright

Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

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Auteurs

Carole Le Coz (C)

Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa.

Bertram Bengsch (B)

Department of Medicine II, University Medical Center Freiburg, Freiburg, Germany.

Caroline Khanna (C)

Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa.

Melissa Trofa (M)

Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa.

Takuya Ohtani (T)

Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.

Brian E Nolan (BE)

Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pa.

Sarah E Henrickson (SE)

Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.

Michele P Lambert (MP)

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.

Taylor Olmsted Kim (TO)

Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, Houston, Tex.

Jenny M Despotovic (JM)

Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, Houston, Tex.

Scott Feldman (S)

Department of Medicine, Division of Allergy and Immunology,Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.

Olajumoke O Fadugba (OO)

Department of Medicine, Division of Allergy and Immunology,Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.

Patricia Takach (P)

Department of Medicine, Division of Allergy and Immunology,Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.

Melanie Ruffner (M)

Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa.

Soma Jyonouchi (S)

Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.

Jennifer Heimall (J)

Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.

Kathleen E Sullivan (KE)

Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.

E John Wherry (EJ)

Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.

Neil Romberg (N)

Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa. Electronic address: rombergn@email.chop.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Common variable immunodeficiency-associated...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Common variable immunodeficiency-associated...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Common variable immunodeficiency-associated...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Common variable immunodeficiency-associated...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Common variable immunodeficiency-associated...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Common variable immunodeficiency-associated...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Déficit immunitaire commun variable › Common variable immunodeficiency-associated...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Bactériémie › Endotoxémie › Common variable immunodeficiency-associated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Common variable immunodeficiency-associated...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Dysgammaglobulinémie › Déficit en IgA › Common variable immunodeficiency-associated...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Common variable immunodeficiency-associated...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Common variable immunodeficiency-associated...