Epidemiology of Neonatal Sepsis and Associated Factors Implicated: Observational Study at Neonatal Intensive Care Unit of Arsi University Teaching and Referral Hospital, South East Ethiopia.
Neonatal sepsis
gram negative
gram positive
risk Factor
Journal
Ethiopian journal of health sciences
ISSN: 2413-7170
Titre abrégé: Ethiop J Health Sci
Pays: Ethiopia
ID NLM: 101224773
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
entrez:
27
8
2019
pubmed:
27
8
2019
medline:
1
2
2020
Statut:
ppublish
Résumé
Globally, sepsis remains one of the major causes of morbidity and mortality in neonates, in spite of recent advances in health care units. The major burden of the problem occurs in the developing world while most evidence is derived from developed countries. The objective of this study was to evaluate the epidemiology of neonatal sepsis and associated factors among neonates admitted to Neonatal Intensive Care Unit (NICU). Hospital based prospective cross-sectional study was conducted from April 2016 to May 2017. Neonates with clinical sepsis were included into the study. Data were analyzed using SPSS version 20. Frequencies, proportion and summary statistics were used to describe the study population in relation to relevant variables. Multivariate logistic regressions were used to assess factors associated with neonatal sepsis. p-values of < 0.05 were considered statistically significant. A total of 901neonates were admitted to NICU of which 303 neonates were admitted with diagnosis of clinical sepsis making the prevalence of neonatal sepsis to be 34%. Bacteremia were confirmed in 88/303(29.3%) of clinical sepsis, and gram-positive bacteria constituted 47/88(53.4%). Of all positive blood cultures, 52/88(59.1%) were reported from late onset sepsis. Coagulase negative staphylococcus (CoNS) accounted for 22/88(25%) followed by E. coli and S. aureus, each contributing 18/88(20.3%) and 16/88(18.2%) respectively. Prolonged PROM, low fifth Apgar score, prematurity and low birth weight were strongly associated with increased risk of neonatal sepsis. Neonates born to mothers who received antibiotics during labor and delivery were at significantly lower risk of acquiring neonatal sepsis. The prevalence of neonatal sepsis was high, and most causes of neonatal sepsis were gram positive bacteria and most bacteria isolates were from late onset sepsis. Obstetric factors were strongly associated with development of neonatal sepsis. Intrapartal antibiotic administration significantly reduces neonatal sepsis.
Sections du résumé
BACKGROUND
BACKGROUND
Globally, sepsis remains one of the major causes of morbidity and mortality in neonates, in spite of recent advances in health care units. The major burden of the problem occurs in the developing world while most evidence is derived from developed countries. The objective of this study was to evaluate the epidemiology of neonatal sepsis and associated factors among neonates admitted to Neonatal Intensive Care Unit (NICU).
METHODS
METHODS
Hospital based prospective cross-sectional study was conducted from April 2016 to May 2017. Neonates with clinical sepsis were included into the study. Data were analyzed using SPSS version 20. Frequencies, proportion and summary statistics were used to describe the study population in relation to relevant variables. Multivariate logistic regressions were used to assess factors associated with neonatal sepsis. p-values of < 0.05 were considered statistically significant.
RESULTS
RESULTS
A total of 901neonates were admitted to NICU of which 303 neonates were admitted with diagnosis of clinical sepsis making the prevalence of neonatal sepsis to be 34%. Bacteremia were confirmed in 88/303(29.3%) of clinical sepsis, and gram-positive bacteria constituted 47/88(53.4%). Of all positive blood cultures, 52/88(59.1%) were reported from late onset sepsis. Coagulase negative staphylococcus (CoNS) accounted for 22/88(25%) followed by E. coli and S. aureus, each contributing 18/88(20.3%) and 16/88(18.2%) respectively. Prolonged PROM, low fifth Apgar score, prematurity and low birth weight were strongly associated with increased risk of neonatal sepsis. Neonates born to mothers who received antibiotics during labor and delivery were at significantly lower risk of acquiring neonatal sepsis.
CONCLUSION
CONCLUSIONS
The prevalence of neonatal sepsis was high, and most causes of neonatal sepsis were gram positive bacteria and most bacteria isolates were from late onset sepsis. Obstetric factors were strongly associated with development of neonatal sepsis. Intrapartal antibiotic administration significantly reduces neonatal sepsis.
Identifiants
pubmed: 31447501
doi: 10.4314/ejhs.v29i3.5
pii: jEJHS.v29.i3.pg333
pmc: PMC6689722
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
333-342Références
Curr Opin Infect Dis. 2004 Jun;17(3):217-24
pubmed: 15166824
Arch Dis Child Fetal Neonatal Ed. 2005 May;90(3):F220-4
pubmed: 15846011
Lancet Infect Dis. 2009 Jul;9(7):428-38
pubmed: 19555902
BMC Pediatr. 2010 Jun 04;10:39
pubmed: 20525358
Ital J Pediatr. 2011 Jul 11;37:32
pubmed: 21745376
Pediatrics. 2012 May;129(5):1006-15
pubmed: 22547779
Kathmandu Univ Med J (KUMJ). 2013 Jan-Mar;11(41):66-70
pubmed: 23774417
J Clin Neonatol. 2012 Jul;1(3):124-30
pubmed: 24027707
Virulence. 2014 Jan 1;5(1):170-8
pubmed: 24185532
BMC Pediatr. 2014 Oct 03;14:248
pubmed: 25280754
Pediatr Infect Dis J. 2015 Jun;34(6):659-61
pubmed: 25806843
BMC Infect Dis. 2015 Mar 15;15:127
pubmed: 25888320
Biomed Res Int. 2015;2015:509484
pubmed: 26146621
Pediatr Neonatol. 2016 Aug;57(4):265-73
pubmed: 26750406
BMC Infect Dis. 2016 Oct 24;16(1):598
pubmed: 27776490
BMC Infect Dis. 2016 Dec 13;16(1):756
pubmed: 27964724
BMC Pediatr. 2017 Jun 6;17(1):137
pubmed: 28587631