Nrf2 signaling attenuates epithelial-to-mesenchymal transition and renal interstitial fibrosis via PI3K/Akt signaling pathways.
Animals
Cadherins
/ genetics
Disease Models, Animal
Epithelial-Mesenchymal Transition
Fibronectins
/ genetics
Fibrosis
/ etiology
Kidney Diseases
/ etiology
Mice
Mice, Knockout
NF-E2-Related Factor 2
/ physiology
Phosphatidylinositol 3-Kinases
/ genetics
Proto-Oncogene Proteins c-akt
/ genetics
Signal Transduction
Transforming Growth Factor beta1
/ genetics
Ureteral Obstruction
/ etiology
Epithelial-to-mesenchymal transition
Kidney fibrosis
Nrf2
Journal
Experimental and molecular pathology
ISSN: 1096-0945
Titre abrégé: Exp Mol Pathol
Pays: Netherlands
ID NLM: 0370711
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
15
02
2019
revised:
10
07
2019
accepted:
12
08
2019
pubmed:
27
8
2019
medline:
27
2
2020
entrez:
27
8
2019
Statut:
ppublish
Résumé
Nrf2 constitutes a therapeutic reference point for renal fibrosis and chronic kidney diseases. Nrf2-related signaling pathways are recognized to temper endothelial-to-mesenchymal transition (EMT) in fibrotic tissue. Nevertheless, the mechanism by which Nrf2 mitigates renal interstitial fibrosis is imprecise. The relationship between Nrf2 and renal interstitial fibrosis was investigated using the unilateral ureteral obstruction (UUO) model of Nrf2 The Nrf2 The results we obtained demonstrate that Nrf2 signaling pathway may perhaps offset the development of EMT, prompted by TGF-β1 and renal interstitial fibrosis. Likewise, the anti-fibrotic effect of Nrf2 was imparted by the inactivation of PI3K/Akt signaling. From our discoveries, we deliver new insight related to the prevention and treatment of kidney fibrosis.
Sections du résumé
BACKGROUND
Nrf2 constitutes a therapeutic reference point for renal fibrosis and chronic kidney diseases. Nrf2-related signaling pathways are recognized to temper endothelial-to-mesenchymal transition (EMT) in fibrotic tissue. Nevertheless, the mechanism by which Nrf2 mitigates renal interstitial fibrosis is imprecise.
METHODS
The relationship between Nrf2 and renal interstitial fibrosis was investigated using the unilateral ureteral obstruction (UUO) model of Nrf2
RESULTS
The Nrf2
CONCLUSIONS
The results we obtained demonstrate that Nrf2 signaling pathway may perhaps offset the development of EMT, prompted by TGF-β1 and renal interstitial fibrosis. Likewise, the anti-fibrotic effect of Nrf2 was imparted by the inactivation of PI3K/Akt signaling. From our discoveries, we deliver new insight related to the prevention and treatment of kidney fibrosis.
Identifiants
pubmed: 31449784
pii: S0014-4800(19)30116-9
doi: 10.1016/j.yexmp.2019.104296
pii:
doi:
Substances chimiques
Cadherins
0
Fibronectins
0
NF-E2-Related Factor 2
0
Transforming Growth Factor beta1
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104296Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.