NK2 receptor-mediated detrusor muscle contraction involves G
Animals
Calcium
/ metabolism
Estrogen Antagonists
/ pharmacology
GTP-Binding Protein alpha Subunits, Gq-G11
/ genetics
Gene Deletion
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Muscle Contraction
/ drug effects
Muscle, Smooth
/ physiology
Receptors, Neurokinin-2
/ physiology
Tachykinins
/ metabolism
Tamoxifen
/ pharmacology
Urinary Bladder
/ physiology
rho-Associated Kinases
/ genetics
NK2 receptor
signal transduction
tachykinins
urinary bladder smooth muscle
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
pubmed:
29
8
2019
medline:
9
4
2020
entrez:
29
8
2019
Statut:
ppublish
Résumé
Tachykinins (TKs) are involved in both the physiological regulation of urinary bladder functions and development of overactive bladder syndrome. The aim of the present study was to investigate the signal transduction pathways of TKs in the detrusor muscle to provide potential pharmacological targets for the treatment of bladder dysfunctions related to enhanced TK production. Contraction force, intracellular Ca
Identifiants
pubmed: 31461351
doi: 10.1152/ajprenal.00106.2019
doi:
Substances chimiques
Estrogen Antagonists
0
Receptors, Neurokinin-2
0
Tachykinins
0
Tamoxifen
094ZI81Y45
rho-Associated Kinases
EC 2.7.11.1
GTP-Binding Protein alpha Subunits, Gq-G11
EC 3.6.5.1
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM